血浆置换治疗对重型肝炎患者病毒载量的影响及临床意义

目的:观察并探讨经血浆置换(PE)治疗后重型肝炎(重肝)患者血清中HBV DNA载量的变化及其临床意义.方法:随机选取48例乙型肝炎病毒标志物阳性的重肝患者,在内科基础治疗上加用PE治疗.观察患者在PE治疗前后血清中HBV DNA载量的变化及各项肝功能指标的变化.结果:48例患者血清HBV DNA载量明显下降,治疗有效组比治疗无效组降低更明显,对肝功能和临床症状的改善也更明显.结论:PE治疗可有效去除重肝患者血清中HBV DNA,从而减轻由其诱发的机体免疫反应,改善临床症状及肝功能,提高患者的存活率.

Level Change of HBV DNA after Plasma Exchange in Patients with Severe Hepatitis and Its Clinical Significance

Objective:To observe and evaluate the level of HBV DNA after plasma exchange(PE) in patients with severe hepatitis and its clinical significance.Methods: Randomized 48 patients who were infected by hepatitis B virus and suffering from severe hepatitis,were treated by PE on the similar basic medical treatment. The level of HBV DNA and liver function before and after PE therapy were examined.Results: It shows that the level of serum HBV DNA was decreased after PE therapy. The level of serum HBV-DNA was obviously decreased and the liver function was also improved in recovering patients comparing the worse patients.Conclusion: The PE therapy can effectively purge the serum HBV DNA in patients with severe hepatitis,reduce the immunoreactions,improve the liver function. Then the survival rate of patients was increased.