3-碘-1H-吡唑并[3,4-b]吡嗪的合成 |
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引用本文: | 匡仁云,郭瑾,周小春,黄春芳.3-碘-1H-吡唑并[3,4-b]吡嗪的合成[J].中国医药工业杂志,2010,41(4). |
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作者姓名: | 匡仁云 郭瑾 周小春 黄春芳 |
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作者单位: | 井冈山大学化学化工学院,江西吉安,343009 |
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摘 要: | 2-氰基吡嗪和氯化亚砜在DMF作用下反应得3-氯-2-氰基吡嗪,经水合肼闭环得3-氨基-1H-吡唑并3,4-6]吡嗪,再经NaNO_2/p-TsOH/K1一步完成重氮化-碘代反应得到3-碘-1H-吡唑并3,4-b]吡嗪,总收率约31%.
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关 键 词: | 3-碘-1H-吡唑并[3 4-b]吡嗪 中间体 合成 |
Synthesis of 3-Iodo-1H-pyrazolo [3,4-b] pyrizine |
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Abstract: | 3-Iodo-1H-pyrazolo 3,4-b] pyrizine was synthesized from 2-cyanopyrazine and thionyl chloride to give 3-chloro-2-cyanopyrazine, which was subjected to cyclization with hydrazine hydrate, followed by diazotization and iodination by NaNO_2/p-TsOH/KI with an overall yield of about 31%. |
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Keywords: | 3-iodo-1H-pyrazolo [3 4-6] pyrizine intermediate synthesis |
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