小于45岁的分化型甲状腺癌患者预后因素分析

目的 探讨影响小于45岁分化型甲状腺癌患者的预后因素。方法 对1985年-1997年间在本院首次治疗年龄小于45岁的全部分化型甲状腺癌患者的资料进行单因素（寿命表法）和多因素分析（Cox比例模型）分析。结果 全部病例共272例，10年生存率为93．0％；单因素分析显示首次治疗时的年龄小于等于20岁、有淋巴结转移或远处转移预后差；多因素分析显示远处转移是影响分化型甲状腺癌预后的独立因素。结论 远处转移是影响小于45岁分化型甲状腺癌预后的独立因素，有远处转移的患者，行全或近全甲状腺切除术，术后行^131I内照射治疗可能有利于提高其生存率。

Differentiated thyroid carcinoma in patients younger than 45 years

Objective To investigate the prognostic factors of differentiated thyroid carcinoma (DTC) in patients younger than 45 years. Methods Clinical data of all patients less than 45 years old at presentation with DTC in our hospital from Jan 1985 to Dec 1997 were analyzed retrospectively. Single variable analysis was performed by life-table method. Multivariate analysis was performed by Cox proportional hazard model. Results Two hundred and seventy two cases were analyzed. The overall 10-year survival rate was 93. 0%. The main prognostic factors influencing survival were age at presentation, the status of lymph node metastasis and distant metastasis; distant metastasis was the risk factor independently influencing survival by multivariate analysis. Conclusions Distant metastasis is the factor influencing survival significantly. The prognosis of these patients without distant metastasis is good. Total or near-total thyroidectomy and postoperative 131I therapy may be essential for a better prognosis in patients with distant metastasis.