Anaerobic pathogenesis: collagenase production by Peptostreptococcus magnus and its relationship to site of infection. |
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Authors: | C J Krepel C M Gohr C E Edmiston S G Farmer |
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Affiliation: | Surgical Microbiology Research Laboratory, Medical College of Wisconsin, Milwaukee 53226. |
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Abstract: | Fifty isolates of Peptostreptococcus magnus from intraabdominal sepsis, nonpuerperal breast abscess, and diabetic foot infections were examined for collagenase activity using bovine type I collagen. Collagenase production was detected in a higher percentage of strains from nonpuerperal breast and diabetic foot specimens (P less than .001). This enzyme may be responsible for P. magnus playing a more central role in the pathogenesis of nonpuerperal breast abscess and diabetic foot disease than in intraabdominal sepsis. |
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