NOTES Hybrid Transvaginal Radical Nephrectomy for Tumor: Stepwise Progression Toward a First Successful Clinical Case |
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Authors: | Rene Sotelo,Robert de Andrade,Golena Ferná ndez,Daniel Ramirez,Eugenio Di Grazia,Oswaldo Carmona,Otto Moreira,Andre Berger,Monish Aron,Mihir M. Desai,Inderbir S. Gill |
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Affiliation: | 1. Centro de Robótica y De Invasión Mínima Unidad de Urología, Instituto Médico La Floresta, Caracas, Venezuela;2. Cleveland Clinic, Cleveland, OH, USA |
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Abstract: | BackgroundNatural orifice translumenal endoscopic surgery (NOTES) has been used to perform nephrectomy in the laboratory; however, clinical reports to date have used multiple abdominal trocars to assist the transvaginal procedure.ObjectiveTo present our stepwise technique development and the first successful clinical case of NOTES transvaginal radical nephrectomy for tumor with umbilical assistance without extraumbilical skin incisions.Design, setting, and participantsThe four transvaginal NOTES procedures were performed at two institutions after obtaining institutional review board approval. Various operative steps were developed experimentally in three clinical cases, and on March 7, 2009, we performed the first successful case of NOTES hybrid transvaginal radical nephrectomy without any extraumbilical skin incisions. Using one multichannel access port in the vagina and one in the umbilicus, laparoscopic visualization, intraoperative tissue dissection, and hilar control were performed transvaginally and transumbilically. The intact specimen was extracted transvaginally.MeasurementsAll perioperative data were accrued prospectively. A stepwise progression to the successful completion of the fourth case is systematically presented.Results and limitationsIntraoperatively, at incrementally more advanced stages of the procedure, the first three NOTES clinical cases were electively converted to standard laparoscopy because of rectal injury during vaginal entry, of failure to progress, and of gradual bleeding during upper-pole dissection after transvaginal hilar control, respectively. The fourth case was successfully completed via transvaginal and umbilical access without conversion to standard laparoscopy. Operative time was 3.7 h, estimated blood loss was 150 cm3, and hospital stay was 1 d. Final pathology confirmed a 220-g, pT1b, 7-cm, grade 2, clear-cell renal cell carcinoma with negative margins. The patient was readmitted for an intraabdominal collection that responded to drainage and antibiotics.ConclusionsWe report our stepwise progression and the initial successful clinical case of NOTES hybrid transvaginal radical nephrectomy for tumor, assisted with only one umbilical trocar. Although transvaginal nephrectomy is feasible in the highly selected patient with favorable intraoperative circumstances, considerable refinements in technique and technology are necessary if this approach is to advance beyond mere anecdote. |
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Keywords: | NOTES Transvaginal Nephrectomy Single-port LESS |
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