Controlled Attenuation Parameter (CAP): A Novel VCTE™ Guided Ultrasonic Attenuation Measurement for the Evaluation of Hepatic Steatosis: Preliminary Study and Validation in a Cohort of Patients with Chronic Liver Disease from Various Causes |
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Authors: | Magali Sasso,Michel Beaugrand,Victor de Ledinghen,Catherine Douvin,Patrick Marcellin,Raoul Poupon,Laurent Sandrin,Vé ronique Miette |
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Affiliation: | ∗ R&D Department, Echosens, Paris, France;† Hepatology, Hôpital Jean Verdier, Bondy, France;‡ Hepatology, Hôpital Haut Lévêque, Bordeaux, France;§ Hepatology, Hôpital Henri Mondor, Créteil, France;¶ Hepatology, Hôpital Beaujon, Clichy, France;‖ Hepatology, Hôpital Saint-Antoine, Paris, France |
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Abstract: | There is a need for noninvasive methods to detect liver steatosis, which can be a factor of liver fibrosis progression. This work aims to evaluate a novel ultrasonic controlled attenuation parameter (CAP) devised to target, specifically, liver steatosis using a sophisticated process based on vibration control transient elastography (VCTE™). CAP was first validated as an estimate of ultrasonic attenuation at 3.5 MHz using Field II simulations and tissue-mimicking phantoms. Performance of the CAP was then appraised on 115 patients, taking the histological grade of steatosis as reference. CAP was significantly correlated to steatosis (Spearman ρ = 0.81, p < 10−16). Area under receiver operative characteristic (ROC) curve (AUC) was equal to 0.91 and 0.95 for the detection of more than 10% and 33% of steatosis, respectively. Furthermore, results show that CAP can efficiently separate several steatosis grades. These promising results suggest that CAP is a noninvasive, immediate, objective and efficient method to detect and quantify steatosis. (E-mail: magali.sasso@echosens.com) |
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Keywords: | Ultrasound attenuation Attenuation Liver Steatosis Steato-hepatitis Nonalcoholic fatty liver disease Elastography Vibration controlled transient elastography VCTE&trade Fibroscan® |
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