| 光枝勾儿茶中红镰霉素苷类成分及其对DPPH清除作用研究 |
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| 引用本文： | 景永帅,杨娟,吴兰芳,张振东,方利.光枝勾儿茶中红镰霉素苷类成分及其对DPPH清除作用研究[J].中国中药杂志,2011,36(15):2084-2087. |
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| 作者姓名： | 景永帅 杨娟 吴兰芳 张振东 方利 |
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| 作者单位： | 中国科学院天然产物化学重点实验室,贵州贵阳,550002 |
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| 基金项目： | 贵州省中药现代化科技产业研究开发专项(黔科合中药专字 [2006] 5041号);贵州省科技计划课题(黔科合院所创能[2009]4010) |
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| 摘 要： | 目的:研究光枝勾儿茶全株中的红镰霉素苷类成分,探讨其对二苯代苦味基肼自由基(DPPH)的清除作用.方法:采用硅胶柱色谱,Sephadex LH-20凝胶柱色谱进行分离纯化,通过波谱学方法鉴定化合物结构,并对化合物进行清除DPPH活性试验.结果:从光枝勾儿茶乙醇提取物的正丁醇部分分离得到3个红镰霉素苷类化合物,分别鉴定为红镰霉素-6-O-β-D-吡喃葡萄糖苷(rubrofusarin-6-O-β-D-glucopyranoside,1),红镰霉素-6-O-β-D-(6'-O-乙酰基)吡喃葡萄糖苷rubrofusarin-6-O-β-D-(6'-O-acetyl) glucopyranoside,2],红镰霉素-6-O-α-L-鼠李糖基-(1-6)-O-β-D-吡喃葡萄糖苷rubrofusarin-6-O-α-L-rhamnosyl(1-6)-O-β-D-glucopyranside,3].对DPPH清除能力试验结果表明:3个化合物对DPPH自由基都有较强的清除能力,对照品VitC、化合物1～3的半清除率浓度IC50(μmol·L-1)大小依次为18.2,40.5,23.3,13.6.结论:化合物1～3均为首次从该植物中分离得到,其中化合物2为新化合物.3个化合物均具有较强的抗氧化活性,其中化合物3的清除效果优于VitC.
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| 关 键 词： | 光枝勾儿茶 红镰霉素苷类 DPPH· |
| 收稿时间： | 2010/11/15 0:00:00 |
Rubrofusarin glucosides of Berchemia polyphylla var. leioclada and their scavenging activities for DPPH radical |
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| JING Yongshuai,YANG Juan,WU Lanfang,ZHANG Zhendong and FANG Li.Rubrofusarin glucosides of Berchemia polyphylla var. leioclada and their scavenging activities for DPPH radical[J].China Journal of Chinese Materia Medica,2011,36(15):2084-2087. |
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| Authors: | JING Yongshuai YANG Juan WU Lanfang ZHANG Zhendong and FANG Li |
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| Institution: | The Key Laboratory of Chemistry for Natural Products, Chinese Academy of Sciences, Guiyang 550002, China;The Key Laboratory of Chemistry for Natural Products, Chinese Academy of Sciences, Guiyang 550002, China;The Key Laboratory of Chemistry for Natural Products, Chinese Academy of Sciences, Guiyang 550002, China;The Key Laboratory of Chemistry for Natural Products, Chinese Academy of Sciences, Guiyang 550002, China;The Key Laboratory of Chemistry for Natural Products, Chinese Academy of Sciences, Guiyang 550002, China |
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| Abstract: | Objective: To study the rubrofusarin glucosides from whole plants of Berchemia polyphylla var.leioclada,and their scavenging activities for 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical.Method: The chemical constituents were isolated and purified via repeated silica gel and Sephadex LH-20 column chromatography.Their structures were elucidated by spectral analysis and the compounds were tested for their scavenging activities on DPPH radical.Result: Three rubrofusarin glucosides compounds were isolated and iden... |
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