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液质联用技术(LC/MS)在中药现代研究中的应用
引用本文:刘荣霞,果德安,叶敏,王巧,张金兰.液质联用技术(LC/MS)在中药现代研究中的应用[J].世界科学技术,2005,7(5):33-40.
作者姓名:刘荣霞  果德安  叶敏  王巧  张金兰
作者单位:[1]中国科学院上海生命科学研究院上海药物研究所/上海中药现代化研究中心,上海201203 [2]北京大学药学院,北京100083
基金项目:科学技术部“创新药物与中药现代化”重大专项(2001BAC01A56):70种中药注射剂指纹图谱研究及其技术平台的建立,负责人:钱忠直,果德安;国家中医药管理局专项基金(2004ZX01):中药指纹图谱关键技术与对照谱库建立的方法学研究,负责人:果德安;科学技术部科技基础性工作专项(2002DEA20021):食品、中药与天然药物有效成分检测技术研究,负责人:王晶.
摘    要:液质联用技术将液相色谱(LC)的高分离效能与质谱(MS)的强大结构鉴定功能结合起来,已逐渐成为中药现代研究的强有力手段.本文以研究实例,从中药化学成分的快速筛选、药材品种鉴定、质量控制方法以及体内代谢几个方面,对液质联用技术在中药现代研究中的应用进行了简要评述,并分析了目前阻碍其广泛应用的主要原因和解决方法.

关 键 词:液质联用技术  中药现代化  质量控制  药材鉴定  中药现代研究  液质联用技术  中药化学成分  质量控制方法  结构鉴定  分离效能  液相色谱  快速筛选  品种鉴定
收稿时间:2005-08-18
修稿时间:2005-09-29

Application of Combined Technique of LC/MS to Modern Research of Traditional Chinese Medicine
Liu Rongxia and Guo De-an.Application of Combined Technique of LC/MS to Modern Research of Traditional Chinese Medicine[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2005,7(5):33-40.
Authors:Liu Rongxia and Guo De-an
Abstract:The combined technique of LC/MS is growing into one of the most powerful analytical techniques for the analysis of traditional Chinese medicine (TCM) since it combines the high efficiency of LC separation with the confident structural identification of mass spectrometric detection. By exemplifying the results of the researches which have recently been carried out by the authors of this article in some widely used medicinal herbs, this article makes a brief comment on the application of LC/MS to the following four aspects in the modern research of TCM: the rapid screening of TCM chemical elements, the identification of the species of medicinal plants, the quality control and the in vivo metabolism of TCM medicinal materials. In addition, it analyzes the main reasons that hold back the widespread application of this technique and puts forward measures for it.
Keywords:combined technique of LC/MS  TCM modernization  quality control  identification of medicinal materials  
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