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| 海洋真菌Aspergillus sp.的二肽类代谢产物的研究 | |
| 引用本文： | 黄永富,孟娜,田黎,裴月湖.海洋真菌Aspergillus sp.的二肽类代谢产物的研究[J].中国药物化学杂志,2006,16(1):37-39. |
| 作者姓名： | 黄永富 孟娜 田黎 裴月湖 |
| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016 2. 沈阳中海生物技术开发有限公司,辽宁,沈阳,110016 3. 青岛科技大学,生物制药系,山东,青岛,266042 |
| 摘 要： | 目的对海洋真菌Aspergillussp.发酵液的乙酸乙酯萃取物进行化学成分的研究。方法采用硅胶柱色谱、凝胶柱色谱、高效液相色谱等手段,利用理化和波谱分析方法,对海洋真菌Aspergillussp.发酵液的乙酸乙酯萃取物的化学成分进行分离鉴定。结果与结论从该真菌发酵液的乙酸乙酯萃取物中分离得到8个二肽类化合物,经光谱数据分析,鉴定它们的结构分别为3-苯甲基-6-异丙基哌嗪-2,5-二酮(1)、3-苯甲基-6-异丁基哌嗪-2,5-二酮(2)、3-苯甲基-6-另丁基哌嗪-2,5-二酮(3)、3,6-二苯甲基哌嗪-2,5-二酮(4)、3-异丁基-6-异丙基哌嗪-2,5-二酮(5)、3-另丁基-6-异丁基哌嗪-2,5-二酮(6)、3-另丁基-6-异丙基哌嗪-2,5-二酮(7)、3-异丁基-吡咯并哌嗪-1,4-二酮(8)。这些化合物均是首次从该真菌代谢物中分离得到。 |
| 关 键 词： | 药物化学 结构鉴定 柱色谱法 海洋真菌 乙酸乙酯萃取物 |
| 文章编号： | 1005-0108（2006）01-0037-03 |
| 收稿时间： | 2005-09-07 |
| 修稿时间： | 2005年9月7日 |
The dipeptide metabolites from the broth of marine fungus Aspergillus sp. |
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| HUANG Yong-fu,MENG Na,TIAN Li,PEI Yue-hu.The dipeptide metabolites from the broth of marine fungus Aspergillus sp.[J].Chinese Journal of Medicinal Chemistry,2006,16(1):37-39. | |
| Authors: | HUANG Yong-fu MENG Na TIAN Li PEI Yue-hu |
| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Shenyang Zhonghai Biotechnology Limited Corporation, Shenyang 110016, China ; 3. Department of Biological Pharmacy, Qingdao University of Science and Technology, Qingdao 266042, China |
| Abstract: | Aim To study the chemical constituents from the broth of marine fungus Aspergillus sp.Methods The compounds were separated by column chromatography and their structures were elucidated based on chemical and spectral analysis.Result and conclusion Eight compounds were isolated from the ethyl acetate extracts of the broth of Aspergillus sp.Their structures were determined as 3-benzyl-6-isopropylpiperazine-2,5-dione(1),3-benzyl-6-isobutylpiperazine-2,5-dione(2),3 benzyl-6-sec-butylpiperazine-2,5-dione(3),3,6-dibenzylpiperazine-2,5-dione(4),3-isobutyl-6-isopropylpiperazine-2,5-dione(5),3-sec-butyl-6-isobutylpiperazine-2,5-dione(6),3-sec-butyl-6-isopropylpiperazine-2,5-dione(7),3-isobutylhexahydro-pyrrolopyrazine-1,4-dione(8).All of the compounds are obtained from this marine fungus for the first time. |
| Keywords: | Aspergillus sp |
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