| 过氧化氢在中性条件下氧化降解壳聚糖的研究 |
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| 引用本文： | 任艳玲,郭益冰,赵亚红,杨宇民. 过氧化氢在中性条件下氧化降解壳聚糖的研究[J]. 南通医学院学报, 2007, 27(4): 254-256 |
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| 作者姓名： | 任艳玲 郭益冰 赵亚红 杨宇民 |
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| 作者单位： | 1. 南通大学神经再生重点实验室,南通,226001;南通大学航海医学研究所,南通,226001
2. 南通大学神经再生重点实验室,南通,226001 |
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| 基金项目： | 江苏省自然科学基金;江苏省教育厅青蓝工程项目 |
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| 摘 要： | 目的:研究制备不同分子量壳聚糖的方法。方法:壳聚糖的水溶液加入一定量的双氧水,加热搅拌一段时间进行降解。结果:分子量为103万的壳聚糖降解得到分子量5万到94万不等壳聚糖,反应时间、舣氧水的质量百分比、反应温度等因素均可对其产生一定影响。结论:中性条件下双氧水降解壳聚糖成本低,反应条件温和,易处理,产量高,可得到预期分子量的壳聚糖。在降解过程中对降解结果产生影响的因素依次为:双氧水的质量百分比>反应温度>反应时间。
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| 关 键 词： | 低分子量壳聚糖 过氧化氢 氧化降解 |
| 文章编号： | 1000-2057（2007）04-0254-03 |
| 收稿时间： | 2007-05-21 |
| 修稿时间： | 2007-05-21 |
The study of hydrogen peroxide oxidize chitosan under the neutral condition |
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| REN Yanling,GUO Yibing,ZHAO Yahong,et al. The study of hydrogen peroxide oxidize chitosan under the neutral condition[J]. ACTA Academiae Medicinae Nantong, 2007, 27(4): 254-256 |
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| Authors: | REN Yanling GUO Yibing ZHAO Yahong et al |
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| Abstract: | Objective: In order to investigate the producing method for chitosan with different molecular weight. Method: The hydrogen peroxide was added into the chitosan water solution, heated and stirred for some time. Results: The molecular weight of the chitosan decreased from 1.03 to 0.05-0.94 million, and the factors such as reaction time, the quality percentage of hydrogen peroxide , reaction temperature and so on affected it. Conclusion: This method has low cost, mild reaction condition, easy treatment and high output, and it can get the expected chitosan. The factors which may affect the results during degradation are as follows: quality percentage of hydrogen peroxide >reaction temperature> reaction time. |
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| Keywords: | Chitosan with low molecular weight Hydrogen peroxide Oxidize degradation |
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