泮托拉唑防治慢性阻塞性肺疾病呼吸衰竭急性加重期消化道出血的临床疗效分析

目的分析泮托拉唑防治慢性阻塞性肺疾病呼吸衰竭急性加重期消化道出血的临床疗效。方法对某院2008年6月～2010年12月收治的COPD呼吸衰竭急性加重期的50例患者采用泮托拉唑进行消化道出血的防治治疗,其疗效与对照组进行分析比较。结果采用泮托拉唑对COPD呼吸衰竭急性加重期的消化道出血的防止治疗后,无1例患者出现消化道出血,仅有少数患者出现反酸、腹胀、腹痛等现象,且无1例患者死亡是因消化道出血所致。两组患者治疗后出现反酸、腹胀、腹痛、出血和消化道出血死亡及死亡的差异比较,差异有统计学意义(P﹤0.05)。结论采用泮托拉唑防治慢性阻塞性肺疾病呼吸衰竭急性加重期的消化道出血,对减少出血的并发率和与消化道出血相关的死亡率有着较好的效果。

Analysis on clinical efficacy of pantoprazole in the prevention of chronic obstructive pulmonary disease with respiratory failure and acute exacerbation of gastrointestinal bleeding

OBJECTIVE To analyze the clinical efficacy of pantoprazole in the prevention of chronic obstructive pulmonary disease with respiratory failure and acute exacerbation of gastrointestinal bleeding.METHODS 50 patients with respiratory failure admitted for acute exacerbation of COPD from June 2008 to December 2010 were treated with pantoprazole treatment for prevention of gastrointestinal bleeding,and its efficacy was compared with the control group for analysis.RESULTS After the treatment of pantoprazole in the prevention of chronic obstructive pulmonary disease with respiratory failure and acute exacerbation of gastrointestinal bleeding,there was no patient with gastrointestinal bleeding.Only a small number of patients were with sour regurgitation,bloating,abdominal pain and other phenomenon,and no patient died due to gastrointestinal bleeding.The differences of sour regurgitation,bloating,abdominal pain,bleeding and gastrointestinal bleeding caused for death for the patients in the two groups after treatment were compared,there was a significant difference(P﹤0.05).CONCLUSION The use of pantoprazole in the prevention of chronic obstructive pulmonary disease with respiratory failure and acute exacerbation of gastrointestinal bleeding has good effect in reducing the complication rate of bleeding and mortality associated with gastrointestinal bleeding.