阿托伐他汀钙预防缺血性脑卒中再发的临床观察

目的探讨阿托伐他汀钙对缺血性脑卒中再发的预防作用。方法将100例首次患缺血性脑卒中的患者经积极治疗病情平稳后,随机分为对照组50例,治疗组50例。对照组常规予以阿司匹林肠溶片100mg/日。治疗组在对照组治疗的基础上予以阿托伐他汀钙20mg/日,共服用1年,分析两组血脂变化、颈动脉斑块积分的变化及缺血性脑卒中再发的比率。结果治疗组低密度脂蛋白胆固醇(2.63±1.25)mmol/L,对照组(4.38±1.85)mmol/L,两组比较差异有统计学意义(t=2.426,P﹤0.05)。治疗组颈动脉斑块积分(4.05±2.16),对照组颈动脉斑块积分(6.51±2.23),两组比较差异有统计学意义(t=2.851,P﹤0.05)。缺血性脑卒中再发的比率治疗组和对照组分别为(5%)和(16%),两组比较差异有统计学意义(χ2=4.80,P﹤0.05)。结论阿托伐他汀钙能有效预防缺血性脑卒中的再发。

Observation on the effect of atorvastatin calcium in preventing the recurrence of ischemic stroke

OBJECTIVE To study on the effect of atorvastatin calcium on ischemic stroke recurrence prevention.METHODS 100 cases of first ischemic stroke patients after active treatment in patients with stable disease were randomly divided into control group and treatment group.The control group received conventional enteric-coated tablets of aspirin 100mg/day.The treatment group received atorvastatin calcium 20mg/day,taking a total of 1 year.We analyzed the changes in blood lipids were analyzed,changes in carotid artery plaque and ischemic stroke risk of recurrence.RESULTS Low-density lipoprotein cholesterol of the treatment group was(2.63±1.25)mmol/L,the control group was(4.38±1.85)mmol/L.Two groups had significant difference(t = 2.426,P﹤0.05).Carotid artery plaque score in treatment group was 4.05±2.16,and the control group was 6.51±2.23.Two groups had significant difference(t = 2.851,P﹤0.05).Ischemic stroke to prevent recurrence rate of treatment group and control groups respectively was(5%)and(16%),Two groups had significant differences(χ2 = 4.80,P﹤0.05).CONCLUSION Atorvastatin calcium can prevent the recurrence of ischemic stroke.