高危型人乳头瘤病毒感染相关危险因素分析

目的探讨宫颈高危人乳头瘤病毒(HPV)感染的危险因素。方法选取郑州大学第三附属医院2009年9月～2011年3月间行高危型HPV(HR-HPV)筛查的门诊或病房患者阳性病例306例,27例HPV-DNA阴性作为对照组,用杂交捕获二代法(HC2)检测HPV-DNA,所有患者均填写HPV感染相关危险因素调查表,单因素和多因素非条件Logistic回归分析的方法对调查信息进行分析。结果经单因素非条件Logistic回归分析,受教育程度,家庭人均收入,第一次结婚年龄、被动吸烟、曾经怀孕、人工流产、使用避孕套、第一次性生活年龄、性伴侣数与HPV感染存在相关性(P﹤0.05)。经多因素非条件Logistic回归分析,家庭人均收入,被动吸烟,使用避孕套,第一次性生活年龄有关(P﹤0.05)。结论被动吸烟、人工流产、性伴侣数多是HPV感染的危险因素(OR﹥1),受教育程度高、经济收入多、使用避孕套、第一次性生活年龄大是HPV感染的保护因素(OR﹤1)。因此应加强对HPV易感人群的卫生宣教与管理,从而预防宫颈癌的发生。

Study of the risk factors of high risk human papilloma viruse infection

OBJECTIVE To investigate risk factors of cervical high risk HPV infection.METHODS Data were collected from the patients who conducted the high risk human papilloma virus test,and at the same time,filled in the questionnaire about the high risk HPV(HR-HPV)infection in the Third Affiliated Hospital of Zhengzhou University from September,2009 to March,2011.The hybrid capture 1I(HC2)method was used to examine the high-risk human papilloma virus.Questionnaire results were analyzed on univariate and multivariate non-conditional Logistic analysis.RESULTS Univariate and multivariate Logistic regression analysis showed there were associations between risk factors for HR-HPV infection and education level,socio-economic state,first marriage age,passive smoking,ever pregnant,artificial abortion,condom use,age at first intercourse and the number of sexual partner(P﹤0.05).CONCLUSION The risk factors for HR-HPV infection include passive smoking,artificial abortion and the number of sexual partner(OR﹥1).The protective factors include higher education lever,higher socio-economic income,condom use and the younger first intercourse age(OR﹤1).So,more attention should be paid to improve the awareness and management of cervical HPV infection,only this,the cervical cancer can be prevented.