| 氯化三苯基锡(TPTC)对家兔糖、脂代谢的影响及其机理的探讨 |
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| 引用本文： | 赵继和,仲来福,夏元洵. 氯化三苯基锡(TPTC)对家兔糖、脂代谢的影响及其机理的探讨[J]. 大连医科大学学报, 1988, 0(1) |
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| 作者姓名： | 赵继和 仲来福 夏元洵 |
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| 作者单位： | 大连医学院，大连医学院卫生学教研室，大连医学院卫生学教研室 八六届研究生 |
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| 摘 要： | 一次经口给予 TPTC20mg/kg 或3.0和5.0mg/kg/天连续14天后,可致血糖和脂类显著增高,血胰岛素明显下降和胰岛 B 细胞的变性坏死。但对肝功、肝脂及胰岛 A 细胞、胰腺外分泌部和肝、肾结构均无明显损害。提示 TPTC 对家免胰岛 B 细胞具有明显的选择性毒效应。
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| 关 键 词： | TPTC 糖 脂代谢 胰岛B细胞选择性毒效应 |
EFFECTS OF TRIPHENYLTIN (TPTC) ON METABOLISM OF GLUCOSE AND LIPIDS IN RABBIT AND ITS POSSIBLE MECHANISM |
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| Zhao Jihe. EFFECTS OF TRIPHENYLTIN (TPTC) ON METABOLISM OF GLUCOSE AND LIPIDS IN RABBIT AND ITS POSSIBLE MECHANISM[J]. Journal of Dalian Medical University, 1988, 0(1) |
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| Authors: | Zhao Jihe |
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| Affiliation: | Zhao Jihe Department of Hygiene,Dalian Medical College |
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| Abstract: | After an oral dose of TPTC at 20 mg/kg,or dailyrepeated oral doses of TPTC at 3.0 or 5.0 mg/kg for 14 consecutivedays,fasting serum glucose and lipids were found to be greatlyincreased,serum immunoreactive insulin (IRI) was lowered sharply,and degeneration and necrosis of pancreatic B-cells were observed,without damage to the hepatic function,lipid content in the liver, and structures of pancreatic A-cells,exocrine pancreas and the liverand the kidneys.It is suggested that TPTC possesses highly selectivetoxicity to pancreatic B-cells in rabbit. |
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| Keywords: | triphenyltin chloride metabolism of glucose and lipids pancreatic B-cell selective toxicity |
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