氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床观察

目的探讨氨氯地平阿托伐他汀钙片应用于高血压合并冠心病的临床疗效。方法以我院2011年7月-2014年3月我院就诊确诊的86例高血压合并冠心病患者为研究对象,按随机数字法随机分为观察组与治疗组,其中治疗组43例,对照组43例;治疗组给予氨氯地平阿托伐他汀片治疗,而对照组采用硝苯地平片治疗,比较两组患者临床治疗效果。结果两组患者进行治疗后,两组患者血压下降,心绞痛症状改善,症状改善总有效率观察组显著高于对照组(P0.05);在观察组LDL-C、TC两项治疗后与治疗前比较显著下降,有统计学差异(P0.05),两组患者均无严重不良事件发生。结论氨氯地平阿托伐他汀片治疗高血压合并冠心病患者具有良好的降压效果,改善冠心病症状,有效降低血脂,临床疗效确切,并且方便依从性高。

Clinical efficacy of amlodipine besylate and atorvastatin calcium tablets in patients with hypertension and coronary heart disease

Objective To investigate the clinical efficacy of amlodipine besylate and atorvastatin calcium tablets in patients with hypertension and coronary heart disease. Methods Eighty-six patients with hypertension and coronary heart disease, who visited our department from July 2011 to March 2014, were included in this study. These patients were randomly divided into treatment group （n=43） and control group （n=43）. Patients in the treatment group were administered amlodipine besylate and atorvastatin calcium tablets, while patients in the control group were given nifedipine tablets. The clinical outcomes of the two groups were compared. Results Blood pressure and angina pectoris were reduced in both groups, while the treatment group had a significantly higher overall response rate in terms of symptom improvement compared with the control group （P〈0.05）. The levels of low-density lipoprotein cholesterol and total cholesterol were significantly reduced after administering amlodipine besylate and atorvastatin calcium tablets in the treatment group （P〈0.05）. There were no adverse events occurring in the two groups. Conclusion Amlodipine besylate and atorvastatin calcium tablets can effectively reduce blood pressure and blood lipids and relieve the symptoms of coronary heart disease in patients with hypertension and coronary heart disease, which means its clinical effect is prominent. Moreover, it is easy to achieve patient compliance.