The significance of ragged-red fibres in neuromuscular disease |
| |
| Authors: | Michael Swash Martin S Schwartz Margaret K Sargeant |
| |
| Institution: | 1. Institute of Pathology and Section of Neurological Sciences, The London Hospital, London E1, Great Britain;2. Department of Neurology, Atkinson Morley''s Hospital, London, SW20 Great Britain |
| |
| Abstract: | The pathological significance of ragged-red fibres is uncertain. We have studied ragged-red fibres in the muscle biopsies of 3 adults; one with polymyositis and two with progressive external ophthalmoplegia. All the ragged-red fibres were Type 1 fibres. In two patients the mean diameter of the ragged-red fibres was significantly smaller than the unaffected Type 1 fibres. Some of these fibres showed features of regeneration, and others of degeneration. In the patient with polymyositis the mitochondria were proliferated and contained osmiophilic dense bodies; in the other two patients paracrystalline mitochondrial inclusions were prominent. These findings suggest that ragged-red fibres do not represent a single pathological process. |
| |
| Keywords: | Correspondence should be addressed to Dr Swash at The London Hospital London E1 1BB |
| 本文献已被 ScienceDirect 等数据库收录！ |
