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| 法莫替丁生物黏附片的处方筛选研究 | |
| 引用本文： | 李东,陈日来,李玉珍,徐玉红,聂中越.法莫替丁生物黏附片的处方筛选研究[J].中国药业,2005,14(8):52-53. |
| 作者姓名： | 李东 陈日来 李玉珍 徐玉红 聂中越 |
| 作者单位： | 1. 暨南大学第二临床医学院、深圳市人民医院,广东,深圳,518020 2. 深圳市福田梅林医院,广东,深圳,518049 3. 广东医学院附属福田医院,广东,深圳,518033 |
| 摘 要： | 目的:筛选和优化法莫替丁生物黏附片的处方.方法:采用3因素9水平的均匀设计,结合多元线性回归的方法,以溶出度为指标,对制剂处方进行筛选、优化.结果:多元线性回归结果表明,处方中生物黏附材料HPMC、卡波姆对药物释放起阻滞作用,方程较好地阐明了主要辅料对法莫替丁生物黏附片释放度的影响.结论:均匀设计优化法莫替丁生物黏附片处方结果良好,优化处方的释放速度达到设计要求. |
| 关 键 词： | 法莫替丁 生物黏附片 均匀设计 处方筛选 |
| 文章编号： | 1006-4931（2005）08-0052-02 |
| 收稿时间： | 2005-04-28 |
| 修稿时间： | 2005年4月28日 |
Optimizing the Formulation of Famotidine Bioadhesive Tablets |
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| Li Dong,Chen Rilai,Li Yuzhen,Xu Yuhong,Nie Zhongyue.Optimizing the Formulation of Famotidine Bioadhesive Tablets[J].China Pharmaceuticals,2005,14(8):52-53. | |
| Authors: | Li Dong Chen Rilai Li Yuzhen Xu Yuhong Nie Zhongyue |
| Abstract: | Objective:To screen and optimize the formulation of famotidine bio ad hesive tablets(FBTs).Methods:A three-factor and nine-level uniform design with multi-line-regression was performed to screen formulation of FBTs.The re leasing behaviors of FBTs were evaluated by release test in vitro.Results:The results of regression showed that the amount of HPMC and carbomer was the main f actor influencing drug release in vitro.The measuring cumulative release of FBT s fitted well the predictive cumulative release from the equation.Conclusion:I t was effective and convenient to optimize the formulation of FBTs by uniform de sign and the drug release rate of FBTs reached the design requirements. |
| Keywords: | famotidine bioadhesive tablet uniform design formulation screening |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |