Serum interleukin 8 levels correlate with synovial fluid levels in patients with aseptic loosening of hip prosthesis |
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Authors: | Tanaka Ryuji Yasunaga Yugi Hisatome Takashi Yamasaki Takuma Iwamori Hiroshi Ochi Mitsuo |
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Affiliation: | Department of Orthopaedic Surgery, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. |
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Abstract: | Levels of inflammatory cytokines (tumor necrosis factor alpha, interleukin [IL] 6, and IL-8) in serum from patients with osteolysis on radiographs after hip arthroplasty [osteolysis(+), n = 28], patients without osteolysis after hip arthroplasty [osteolysis(-), n = 24], and nonoperated healthy subjects [controls, n = 20] were determined. In addition, cytokine levels in synovial fluid from patients undergoing revision total hip arthroplasty (n = 14) for loosening were measured and compared with each other and with the area of osteolysis on radiographs. Serum IL-6 and IL-8 levels were significantly higher in the osteolysis(+) group than in the osteolysis(-) or the control groups. Furthermore, a significant correlation was found between the serum and synovial fluid IL-8 levels and between synovial fluid IL-8 levels and the area of osteolysis in patients undergoing revision total hip arthroplasty. Therefore, serum IL-8 levels could be a useful periprosthetic osteolysis marker. |
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Keywords: | aseptic loosening periprosthetic osteolysis serum synovial fluid cytokines interleukin 8 |
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