Positive serology for<Emphasis Type="Italic"> Helicobacter pylori</Emphasis> and vomiting in the pregnancy |
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Authors: | Email author" target="_blank">Haim?ShirinEmail author Oscar?Sadan Orit?Shevah Rafael?Bruck Mona?Boaz Steven?F?Moss Samuel?Everon Marek?Glezerman Yona?Avni |
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Institution: | (1) Department of Gastroenterology, E. Wolfson Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, 58100 Holon , Israel;(2) Obstetrics and Gynecology, E. Wolfson Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, 58100 Holon, Israel;(3) Epidemiology Unit, E. Wolfson Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, 58100 Holon, Israel;(4) Department of Medicine, Gastroenterology Division, Brown University, Providence, RI, USA |
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Abstract: | Introduction. Recently, several investigators have suggested that H. pylori may be a contributory factor in hyperemesis gravidarum. The purpose of this study was to evaluate whether seropositivity
for IgG antibodies to H. pylori may also be related to nausea, vomiting, heartburn and epigastric pain in pregnancy.
Materials and methods. One hundred and eighty-five women, at term pregnancy, were included in the study. All women completed a questionnaire regarding
information on the number of pregnancies and deliveries, weight gain, smoking and gastrointestinal complaints before and during
pregnancy. The presence of H. pylori infection was determined by serology.
Results. The overall prevalence rate of H. pylori seropositivity was 45.9%. Women positive for H. pylori IgG were older (28.7±4.5 vs. 27.0±4.5, p=0.02), had more prior pregnancies (3.2±2.1 vs. 2.6±1.6, p=0.02) and deliveries (2.6±1.6 vs. 2.0±1.1, p=0.006) and reported vomiting in the first trimester more frequently than H. pylori negative patients (81.2% vs. 65%, p=0.004). On the other hand vomiting in the second trimester was reported more frequently among smokers during pregnancy compared
to non-smokers.
Conclusions.
H. pylori seropositivity is significantly associated with emesis gravidarum but not with gastro-intestinal symptoms later in pregnancy.
First trimester vomiting more than doubles the likelihood that the gravida is H. pylori IgG positive. |
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Keywords: | Helicobacter pylori Pregnancy Vomiting Heartburn |
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