雷公藤多甙(T_Ⅱ)对肾移植大鼠外周血可溶性白细胞介素2受体的影响 |
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引用本文: | 钱叶勇,石炳毅,李静,徐志兰,史迎昌,冯端浩. 雷公藤多甙(T_Ⅱ)对肾移植大鼠外周血可溶性白细胞介素2受体的影响[J]. 中国中西医结合杂志, 2003, 0(Z1) |
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作者姓名: | 钱叶勇 石炳毅 李静 徐志兰 史迎昌 冯端浩 |
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作者单位: | 解放军第三零九医院移植外科 中国中医研究院西苑医院 解放军第三零九医院移植外科 (北京100091) (北京100091) |
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摘 要: | 目的:探讨雷公藤多甙(T_Ⅱ)对同种异体大鼠的免疫抑制机制。方法:将肾移植大鼠分为3组:对照组、T_Ⅱ组与环抱素 A(CsA)组。检测肾移植大鼠术后外周血可溶性白细胞介素2受体(SIL-2R)的变化及其与移植大鼠存活的关系。结果:对照组大鼠平均存活(7.3±2.2)天,sIL-2R 平均水平为(39.4±11.6)U/ml;T_Ⅱ组大鼠平均存活(18.1±3.7)天,sIL-2R 平均(27.6±10.4)U/ml;CsA 组大鼠平均存活(26.1±4.6)天,sIL-2R 平均(18.2±9.2)U/ml。T_Ⅱ组大鼠存活时间比对照组明显延长(P<0.01),但不及 CsA 组(P<0.05),sIL-2R 水平低于对照组(P<0.05),高于 CsA 组(P<0.05)。结论:T_Ⅱ可以显著抑制移植大鼠外周血 sIL-2R 水平,sIL-2R 外周血水平与移植鼠存活时间呈明显负相关
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关 键 词: | 雷公藤多甙 肾移植 可溶性白细胞介素2受体 |
Effect of Total Glucosides of Tripterygium wilfordii(T_Ⅱ)on Peripheral Soluble Interleukin-2 Receptor of Renal Transplanted Rats |
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Affiliation: | QIAN Ye-yong SHI Bing-yi LI Jing Department of Urology; The 309 Hospital of PLA.Beijing(100091); |
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Abstract: | Objective:To explore the immuno-inhibition mechanism of total glucosides of Tripterygium wilfordii (T_Ⅱ) on homologuous rats,Methods:Renal transplanted rats were divided into three groups:the control group,total glucosides of Tripterygium wilfordii group (T_Ⅱ group) and cyclosporin A (CsA group).Changes of post-operational peripheral soluble interleukin-2 receptor (sIL-2R) in renal transplanted rats were tested and its relation with the survivals of transplanted rats was also observed.Results:The average su... |
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Keywords: | total glucosides of Tripterygium wilfordii renal transplantation soluble interleukin-2 receptor |
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