Pancreatic B-cell function in relation to diabetic retinopathy in Asian Indian NIDDM patients |
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Authors: | Chamukuttan Snehalatha Rema Mohan Viswanathan Mohan Ambady Ramachandran Moopil Viswanathan |
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Institution: | (1) Diabetes Research Centre and M. V. Hospital for Diabetes, Madras, India;(2) Department of Biochemistry, Diabetes Research Centre, 5, Main Road, Royapuram, 600 013 Madras, India |
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Abstract: | Summary Pancreatic B-cell function in relation to diabetic retinopathy was studied in 195 NIDDM patients with long-standing diabetes.
Background diabetic retinopathy (BDR) was present in 95 (48.7%) and proliferative retinopathy (PDR) in 17 (8.7%) of the subjects.
There was no significant difference between the BDR, PDR, and non-retinopathy groups with respect to age, age at diagnosis
of diabetes and HbA1 values. Mean duration of diabetes was higher in the PDR group (p<0.05). Serum C-peptide values showed no correlation with
the presence of retinopathy or with the duration of diabetes. The C-peptide values were widely scattered in patients with
BDR and PDR showing no association between pancreatic B-cell reserve and occurrence or severity of retinopathy in NIDDM patients.
Thus, decreased pancreatic B-cell reserve does not appear to be a risk factor for diabetic retinopathy in NIDDM patients. |
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Keywords: | B-cell function Diabetic retinopathy Microvascular complications Serum C-peptide |
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