| 三氧化二砷作用机制研究进展 |
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| 作者姓名： | Feng CQ Ma WL Zheng WL |
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| 作者单位： | 1. 第一军医大学分子生物学研究所,广东广州,510515
2. 广州军区总医院分子肿瘤研究所,广东广州,510010 |
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| 摘 要： | 砷化合物在我国作为药物应用已有2400多年的历史了。自从20世纪90年代,我国学者应用三氧化二砷（As2O3）治疗急性早幼粒细胞性白血病并获得成功以来,人们对砷化合物进行了深入的研究,发现As2O3不仅对各型白血病有效,对其他多种恶性肿瘤也有良好的治疗效果。As2O3主要是通过抑制肿瘤细胞生长和肿瘤新生血管形成、诱导肿瘤细胞部分分化和凋亡等发挥抗肿瘤作用的。本文不仅对上述问题进行总结,还展望了新发展起来的基因表达谱分析技术--基因芯片技术在研究As2O3作用机制方面的应用前景。
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| 关 键 词： | 三氧化二坤 作用机制 肿瘤 凋亡 |
| 文章编号： | 1000-467X(2002)12-1386-04 |
| 修稿时间： | 2002年4月3日 |
Research advances on effect of arsenic trioxide on tumor |
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| Feng CQ,Ma WL,Zheng WL.Research advances on effect of arsenic trioxide on tumor[J].Chinese Journal of Cancer,2002,21(12):1386-1389. |
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| Authors: | Feng Chun-qiong Ma Wen-li Zheng Wen-ling |
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| Institution: | Institute of Molecular Biology, First Military Medical University, Guangzhou 510515, P. R. China. feng1215@fimmu.edu.cn |
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| Abstract: | Arsenic compounds are natural substances that have been used medically for more than 2 400 years in China. Since 1990s, Chinese physicians have began to use arsenic trioxide in treating the patients with acute promyelocytic leukemia (APL), and the results showed that arsenic trioxide was effective on APL patients. Further study of arsenic trioxide demonstrated that arsenic trioxide was safe and effective not only on patients with leukemia, but also on patients with many other kinds of malignant cancers. Arsenic trioxide exerted its anti cancer effects mainly by inhibiting the cell growth and angiogenesis, inducing the cell partial cytodifferentiation and apoptosis, etc. In addition, this review looked forward to the prospect of application of gene chip, a newly developed and powerful technology in analysis of gene expression profile, in elucidation of the mechanism of arsenic trioxide on tumor. |
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| Keywords: | Arsenic trioxide Mechanism Tumor Apoptosis |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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