Metabotropic glutamate receptors: an original family of G protein-coupled receptors |
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| Authors: | J Bockaert J Pin and L Fagni |
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| Institution: | CNRS UPR 9023, rue de la Cardonille, 34094 Montpellier Cedex 5, France |
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| Abstract: | Summary— In 1985, we discovered a new glutamate receptor which was coupled to phospholipase C via a G protein and which was later termed metabotropic glutamate receptor (mGluR). In this review, both the diversity of mGluRs and the cellular events they control are discussed, as well as their roles in physiological regulation and brain function. |
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| Keywords: | glutamate receptors metabotropic receptors G proteins second messengers synaptic plasticity |
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