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| CYP2J2基因和EPHX2基因多态性与肺癌易感性研究 | |
| 引用本文： | 汤陵,于世英,丁虎,汤应雄,汪道文,严江涛.CYP2J2基因和EPHX2基因多态性与肺癌易感性研究[J].临床内科杂志,2009,26(5):349-351. |
| 作者姓名： | 汤陵 于世英 丁虎 汤应雄 汪道文 严江涛 |
| 作者单位： | 1. 华中科技大学同济医学院附属同济医院肿瘤科,武汉,430030 2. 华中科技大学同济医学院附属同济医院心血管内科,武汉,430030 3. 华中科技大学同济医学院附属同济医院普胸外科,武汉,430030 |
| 摘 要： | 目的探讨CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性与肺癌发生的关系。方法经病理检查确诊为肺癌患者150例（肺癌组），300名本院健康体检者作为对照组，检测其CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性，并进行统计学分析。结果肺癌组和对照组比较，CYP2J2启动子区G-50T多态性差异无统计学意义，而肺癌组患者EPHX2 860G等位基因频率显著高于对照组人群（96％比78．3％，P〈0．01），多元回归分析方法显示，肺癌的发生与EPHX2 G860A多态性显著相关（校正OR值=0．164，95％CI 0．079～0．342，P〈0．001）。结论EPHX2 G860A多态件与肺痛密切相关．可作为肺癌高毹患者的预涮指标． |
| 关 键 词： | 肺癌 CYP2J2 EPHX2 基因多态性 |
Polymorphism s of CYP2J2 and EPHX2 genes and genetic susceptibility of Lung cancer |
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| Institution: | TANG Ling, YU Shiying, DING Hu, et al.( Department of oncology, tongji hospital of tongji medical college, huazhong university of science and technology, Wuhan 430030, China) |
| Abstract: | Objective To investigate the association between the CYP2J2 gene G-50T and EPHX2 gene G860A polymorphism and lung cancer.Methods One hundred and fifty patients with lung cancer and 300 healthy people as control group were collected.The CYP2J2 gene G-50T and EPHX2 gene G860A polymorphisms were detected and analyzed.Results The allele frequency of EPHX2 gene 860 G in patients with lung cancer was significantly higher than that in control group (96% vs 78.3%,P<0.01).Logistic regression analysis showed that EPHX2 gene G860A polymorphisms was associated to lung cancer significantly(adjusted OR:0.164,95%CI 0.079～0.342,P<0.001).However,there was no significantly association between CYP2J2 gene G-50T polymorphism and lung cancer.Conclusion EPHX2 gene G860A polymorphism is associated with lung cancer,which could become a predictor of lung cancer in high risk population. |
| Keywords: | CYP2J2 EPHX2 Lung cancer CYP2J2 EPHX2 Gene polymorphism |
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