| 脂质体阿霉素治疗小鼠淋巴瘤的实验研究 |
| |
| 引用本文： | 吴开达 范健. 脂质体阿霉素治疗小鼠淋巴瘤的实验研究[J]. 中国药理学通报, 1993, 9(4): 268-270 |
| |
| 作者姓名： | 吴开达 范健 |
| |
| 作者单位： | 南京铁道医学院血液室 江苏210009(吴开达，高雪芝)，南京铁道医学院普外科 江苏210009(范健)，南京铁道医学院血液室 江苏210009(金宝翠) |
| |
| 摘 要： | 将阿霉素包封在多层脂质体中,治疗小鼠淋巴瘤,证明阿霉素脂质体的疗效显著优干游离阿霉素。游离阿霉素仅对SRS淋巴瘤小鼠的生存期延长l.5倍,而1mg·kg~(-1)脂质体阿霉素则使其生存期延长3倍,其中30d的存活率为100％,60d的存活率为60％。急性LD_(50)结果表明,脂质体阿霉素毒性较游离阿霉素明显减轻。
|
| 关 键 词： | 脂质体 阿霉素 SRS淋巴瘤小鼠 |
Study on the efficacy of encapsulated adriamycin in the liposomes on mice SRS lymphoma |
| |
| WU Kai-Da,FAN Jian,GAO Xie-Zhi,JIN Bao-Cui. Study on the efficacy of encapsulated adriamycin in the liposomes on mice SRS lymphoma[J]. Chinese Pharmacological Bulletin, 1993, 9(4): 268-270 |
| |
| Authors: | WU Kai-Da FAN Jian GAO Xie-Zhi JIN Bao-Cui |
| |
| Abstract: | Adriamycin (ADM) was encapsulated in multivesicular lipasomes which composed of lipids of eggs origin. The chemothera-peutic activity of the encapsulated ADM was compared with that of free ADM at equal doses in micc bearing SRS lymphoma. The results showed that encapsulation of ADM into lipo-somes resulting in markedly increased efficacy than free ADM. At the dose of 1 mg·kg-1 (every 24 h for 3 separate intraperitoneal injections) , free ADM and ADM entrapped intolipasomes with the same dose had 1. 5 times and 3 times increase the survival time of SRS lymphoma mice respectively as compared with that of the control. The curative rate of mice treated by liposome ADM was 100% on 30 days and 60% on 60 days. The results of LD50 determination showed that the acute toxicity of mice treated by liposome ADM was much less than that of the mice treated with free ADM. |
| |
| Keywords: | liposome adriamycin SRS lymphoma mice |
| 本文献已被 CNKI 维普 等数据库收录！ |
