硝苯吡啶缓释片的蓄积性研究

本文报告６名健康志愿者，每１２ｈ口服硝苯吡啶缓释片２０ｍｇ，连服４ｄ，不同时间静脉取血，用高效液相色谱法测定血浆中硝苯吡啶的含量。结果表明，多次服用硝苯吡啶缓释片后，硝苯吡啶的最高稳态血浓度为１３８ｎｍｏｌ／Ｌ，最低稳态血浓度为５２ｎｍｏｌ／Ｌ，波动指数为０．９１，蓄积因子为１．２。硝苯吡啶缓释片每次２０ｍｇ，每天２次连续服药既能保证药效，又无蓄积。

STUDY OF NIFEDIPINE SUSTAINED-RELEASE TABLETS AND NIFEDIPINE ACCUMULATION

After oral administration of 20 mg nifedipine sustained-release tablets to 6 healthy volunteers two times a day for a period of 4 days,the plasma concentrations of nifedipine at different time intervals were determined by high-performance liquid chromatography.The results showed that C of nifedipine was 138 nmol/L,C 52 nmol/L,fluctuation index 0.91 and the accumulation factor 1.2. It is obvious that continuous administration of 20 mg nifedipine sustained-release tablets two times a day can maintain its pharmacologic effect with no accumulation.