| 加味小柴胡汤对醋氨酚所致肝损伤的保护作用 |
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| 引用本文： | 谢斌,俞大军,程绍民. 加味小柴胡汤对醋氨酚所致肝损伤的保护作用[J]. 时珍国医国药, 2008, 19(1): 130-131 |
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| 作者姓名： | 谢斌 俞大军 程绍民 |
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| 作者单位： | 江西中医学院,江西,南昌,330006 |
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| 摘 要： | 目的 研究加味小柴胡汤对醋氨酚所致肝损伤的保护作用.方法 以醋氨酚致肝损伤动物为模型,观察小鼠脂质过氧化物(LPO)、谷胱甘肽(GSH)、白介素-2(IL-2)、白介素-6(IL-6)及肝组织的病理学检查,探讨加味小柴胡汤保护肝损伤的作用和机理.结果 加味小柴胡汤能降低小鼠LPO,IL-6,升高GSH,IL-2水平,改善肝组织病变.结论 加味小柴胡汤对醋氨酚所致肝损伤有明显的保护作用,其机制可能与抗氧化及免疫调节有关.
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| 关 键 词： | 加味小柴胡汤 醋氨酚 肝损伤 机制 加味小柴胡汤 醋氨酚 保护肝损伤 的保护 作用 Paracetamol Induced Hepatic Injury Decoction Minor Modified 免疫调节 抗氧化 机制 改善 水平 结果 机理 检查 病理学 |
| 文章编号： | 1008-0805（2008）01-0130-02 |
| 收稿时间： | 2007-03-28 |
| 修稿时间： | 2007-05-22 |
Protective Effect of Modified Minor Radix Bupleum Decoction on Hepatic Injury Induced by Paracetamol |
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| XIE Bin,Yu Da-jun,CHENG Shao-min. Protective Effect of Modified Minor Radix Bupleum Decoction on Hepatic Injury Induced by Paracetamol[J]. Lishizhen Medicine and Materia Medica Research, 2008, 19(1): 130-131 |
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| Authors: | XIE Bin Yu Da-jun CHENG Shao-min |
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| Abstract: | Objective To study the protective effect of Modified minor Radix Bupleuri Decoction on hepatic injury induced by Paracetamol. Methods With hepatic injury animal model, we observed LPO, GSH, IL - 2, IL - 6,liver histopathology of mice to investigate the effect and mechanism of modofied minor Radix Bupleuri Decoction on hepatic injury caused by paracetamol. Results Modified Minor Radix Bupleuri Decoction could depress levels of LPO and IL - 6, and increase the levels of GSH and IL - 2, ameliorate pathological changes of hepatic tissue. Conclusion Modified Minor Radix Bupleuri Decoction has obvious protective effect on hepatic injury caused by paracetamol. Its mechanism maybe concerned with antioxidation and immunomodulation. |
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| Keywords: | Modified Minor Radix Bupleuri Decoction Paracetamol Hepatic injury Mechanism |
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