AMI患者治疗前后血NO/NOS和ET检测的临床意义

目的:探讨了急性心肌梗死(AMI)患者治疗前后血NO/NOS和ET含量的变化。方法:应用酶法和放免法检测了30例AMI患者血NO/NOS和ET的含量,并与35名正常健康人作比较。结果:AMI患者治疗前血NO水平显著地低于正常人组(P<0.01),而NOS和ET又非常显著地高于正常人组(P<0.01),经治疗后一个月血NO、NOS与正常人比较无显著性差异(P>0.05),而ET与正常人比较仍有显著性差异(P<0.05)。结论:检测AMI患者血NO/NOS和ET水平对临床观察预后有重要的价值。

Clinical Significance of Measurement of Changes in Serum NO/NOS Ratio and Plasma ET Content After Treatment in Patients with Acute Myocardial Infarction (AMI)

Objective To study the clinical significance of changes of plasma ET and serum NO/NOS ratio in patients with AMI after treatment. Methods Serum NO/NOS ratio (with EIA) and plasma ET (with RIA) contents were measured in 30 patients with acute myocardial infarction both before and after treatment as well as in 35 controls. Results Serum levels of NO were significantly lower (P<0.01) in patients with acute myocardial infarction, but serum NOS and plasma ET levels were significantly higher (P<0.01) than those in the controls before treatment. One months after treatment the serum levels of NO and NOS in the patients were not much different from those in the controls (P>0.05), but plasma ET levels remained significantly higher (P<0.05). Conclusion Changes of serum NO/NOS ratio and plasma ET contents after treatment might be of prognostic importance in patients with acute myocardial infarction.