Salivary and Serum Antibody Response Against Neisseria meningitidis After Vaccination With Conjugate Polysaccharide Vaccines in Ethiopian Volunteers |
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| Authors: | G K Bårnes B Workalemahu P A Kristiansen D Beyene B Merdekios P Fissiha A Aseffa D A Caugant L M Næss |
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| Institution: | 1. Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway;2. Department of Community Medicine, Section 3. of International Community Health, University of Oslo, Oslo, Norway;4. Arba Minch College of Health Sciences, Arba Minch, Ethiopia;5. Armauer Hansen Research Institute, Addis Ababa, Ethiopia;6. College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia;7. Arba Minch General Hospital, Arba Minch, Ethiopia |
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| Abstract: | Meningococcal conjugate vaccines induce serum antibodies crucial for protection against invasive disease. Salivary antibodies are believed to be important for hindering meningococcal acquisition and/or clearance of established carriage. In this study, we measured salivary IgA and IgG antibodies induced by vaccination with a monovalent serogroup A conjugate vaccine or a tetravalent A, C, W and Y conjugate vaccine, in comparison with antibody levels in serum. Saliva and serum samples from Ethiopian volunteers (1–29 years) collected before and eight times on a weekly basis after receiving the serogroup A conjugate vaccine, the tetravalent serogroup A, C, W and Y conjugate vaccine, or no vaccine (control group), were analysed using a multiplex microsphere immunoassay for antibody detection. Serogroup‐specific IgG antibody levels in saliva increased significantly after vaccination with both vaccines. The monovalent serogroup A vaccine also induced an increase in salivary IgA antibodies. A strong correlation between serogroup‐specific IgG antibodies in saliva and serum, and a somewhat lower correlation for IgA, was observed for all serogroups. There was also a strong correlation between specific secretory IgA and IgA antibodies in saliva for all serogroups. Meningococcal conjugate vaccines are able to elicit salivary antibodies against serogroup A, C, W and Y correlating with antibody levels in serum. The strong correlation between saliva and serum antibody levels indicates that saliva may be used as a surrogate of systemic antibody responses. |
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