腺苷脱氨酶检测在胸腔积液中的诊断价值

目的探讨腺苷脱氨酶（ADA）检测在胸腔积液诊断中的应用价值。方法采用酶动力学法分别检测临床诊断明确的32例结核性胸膜炎患者和24例肿瘤性胸腔积液患者胸水ADA,比较其活性及阳性率。结果结核性胸水组ADA活性为（32.4±10.3）u/L明显高于肿瘤性胸水组（15.8±6.2）u/L,差异有统计学意义（P〈0.01）。诊断结核性胸膜炎的敏感性为90.6%,特异性为83.3%。结论胸水ADA活性检测诊断结核性胸膜炎具有高敏感性和高特异性,可常规作为结核性胸水与肿瘤性胸水鉴别的重要参考指标。

Direct detection of adenosine deaminase in the diagnosis of pleural effusion

Objective deaminase（ADA） detected in the pleural effusion of value.Methods Were determined with enzyme kinetics of 32 cases of clinically diagnosed patients with tuberculous pleurisy and 24 patients with cancer of the pleural effusion pleural effusion ADA,to compare their activity and the positive rate.Results ADA activity in tuberculous pleural effusion group was（32.4±10.3） u / L was significantly higher than that of neoplastic pleural effusion group（15.8±6.2） u / L,the difference was statistically significant（P〈0.01）.Diagnosis of tuberculous pleurisy with a sensitivity of 90.6%,specificity was 83.3%.Conclusion ADA activity in diagnosis of pleural effusion of tuberculous pleurisy with high sensitivity and high specificity can be conventional as tuberculous pleural effusion and malignant pleural effusion important reference for identification.