COX-2、MMP-9在甲状腺癌中的表达及临床意义

目的探讨COX-2、MMP-9在甲状腺癌中的表达及其临床意义。方法免疫组化法检测COX-2、MMP-9在甲状腺癌、甲状腺瘤、结节性甲状腺肿及及正常甲状腺组织的表达情况,并对临床病理特征及淋巴结转移进行对比分析。结果 COX-2、MMP-9在甲状腺癌中的表达明显高于甲状腺良性病变,与年龄、肿瘤大小、肿瘤包膜性、临床分期有密切关系（P〈0.05）,COX-2与淋巴结转移有显著相关（P〈0.05）。COX-2、MMP-9均与性别无明显关系（P〉0.05）。结论 COX-2和MMP-9可作为甲状腺癌重要的恶性生物学指标,检测COX-2和MMP-9有助于术前诊断甲状腺癌及判定淋巴结转移、肿瘤浸润情况,使患者得到及时有效治疗。

Clinical Significances of Expression of COX-2,MMP-9 in Thyroid Carcinoma

Objective To discuss the expression and clinical significance of COX-2,MMP-9 in thyroid carcinoma.Methods Expression of COX-2,MMP-9 are detected in thyroid carcinoma、thyroid adenoma、nodular goiter and normal thyroid tissue by immunohistochemical method.Results Expression of COX-2,MMP-9 in thyroid carcinoma groups are obviously higher than that of thyroid benigh tumors,which presents an intimate relationship with age,tumor size,membrane integrality and clinical stage（P〈0.05）,the expression of COX-2 is correlated with lymph node metastasis（P〈0.05）,but negatively correlated with patient gender（P〉0.05）.Conclusion Detection of COX-2 and MMP-9 can act as an preoperative diagnosis method for thyroid cancer and an evaluation of lymph node metastasis and tumor infiltration as an malignant biological indicator,which provide an effective treatment for patients.