| 甲胎蛋白异质体3和高尔基体蛋白73检测在原发性肝癌诊断中的临床意义 |
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| 引用本文： | 赵建忠,李智山,许东强,洪波.甲胎蛋白异质体3和高尔基体蛋白73检测在原发性肝癌诊断中的临床意义[J].中国实验诊断学,2011,15(9):1522-1524. |
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| 作者姓名： | 赵建忠 李智山 许东强 洪波 |
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| 作者单位： | 1. 襄阳市中心医院医学检验部,湖北,襄阳441021
2. 襄阳市中心医院消化科,湖北,襄阳441021 |
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| 摘 要： | 目的探讨血清中甲胎蛋白异质体（AFP-L3）和高尔基体蛋白73（GP73）在原发性肝癌诊断中的临床意义。方法收集原发性肝癌（45例）、肝硬化（35例）、慢性肝炎（36例）、健康对照组（40例）共156个血清样本,采用亲和吸附法和酶联免疫吸附法测定AFP-L3与GP73含量,计算AFP-L3占总AFP的比例（%）。结果 AFP-L3比值在肝癌组为15.60±5.28,显著高于肝硬化组（7.86±2.33）、肝炎组（7.27±2.43）和健康组（6.42±1.56）;GP73含量变化范围为38.06±7.03（健康组）-129.16±28.68（肝癌组）,统计学上差异显著（P〈0.05）。肝癌组中AFP-L3比值阳性率与GP73含量阳性率均显著高于其它各组。AFP-L3比值和GP73含量诊断原发性肝癌的ROC曲线下面积分别为0.933和0.936。结论血清中AFP-L3和GP73浓度可以作为原发性肝癌临床诊断的分子标志物。
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| 关 键 词： | 原发性肝癌 AFP-L3 GP73 分子标志物 |
To Evaluate the Capability of Serum Alpha-fetoprotein-L3 and Golgi protein 73 in Diagnosing Primary Liver Cancer |
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| ZHAO Jian-zhong,LI Zhi-shan,XU Dong-qiang,et al..To Evaluate the Capability of Serum Alpha-fetoprotein-L3 and Golgi protein 73 in Diagnosing Primary Liver Cancer[J].Chinese Journal of Laboratory Diagnosis,2011,15(9):1522-1524. |
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| Authors: | ZHAO Jian-zhong LI Zhi-shan XU Dong-qiang |
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| Institution: | ZHAO Jian-zhong1,LI Zhi-shan1,XU Dong-qiang2,et al.(Xiangyang City Hospital 1.Department of clinical laboratory,2.Department of Gastroenterology,Xiangyang 441021,China) |
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| Abstract: | Objective To analyze the clinical values of alpha-fetoprotein-L3(AFP-L3) and golgi protein 73(GP73) in diagnosing primary liver cancer.Methods The affinity microcentrifugalcolumn method and enzyme-linked immunosorbent assay were employed to detect the serum level of AFP-L3 and GP73 in 45 cases of primary liver cancer,35 cases of liver cirrhosis,36 cases of chronic hepatitis B and 40 healthy controls.The proportion of AFP-L3/AFP(%) was calculated in the following analyses.Results Serum level of AFP-L3(%) in ... |
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| Keywords: | Primary Liver Cancer AFP-L3 GP73 Biomarkers |
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