食管癌和环氧合酶-2关系的研究进展

环氧化酶是花生四烯酸代谢中的一种限速酶,其中的同工酶之一的环氧合酶-2,通过多种途径与诸多肿瘤的发生、发展和预后密切相关.食管癌具有高发病率和死亡率,近年来认为环氧合酶-2通过异型生物质(xenobiotic)代谢,抑制凋亡,参与慢性炎症、免疫抑制,上调血管生成因子的表达,以及促进肿瘤的浸润和转移在其致癌中起重要作用.实验证据表明利用选择性环氧合酶-2抑制剂抑制环氧合酶-2活性可以预防各种组织中肿瘤的形成,包括食管癌.本文就环氧合酶-2对食管癌的致癌作用及选择性环氧合酶-2抑制剂的预防和/或治疗作用作一综述.

Advance of the relationship between esophageal cancer and cyclooxygenase-2

Cyclooxygenase(COX)is a rate-limiting enzyme in the arachidonate metabolism.COX-2,as one of the isoenzymes of COX,is responsible for the pathogenesis,development,metastasis and prognosis of carcinoma through various mecha- nisms.Esophageal cancer is one of the common cancers with high incidence and high mortality. It is reported that COX-2 plays important roles in it,through xenobiotic metabolism,inhibiting apoptosis,development of inflammation-stim- ulated hyperplasia and metaplasia,suppressing host immune responses,inducing angiogenesis and promoting infiltration and metastasis.Re- cently,some trials demonstrated that selective COX-2 inhibitors can inhibit COX-2 to prevent carcinogenesis.In this article,we reviewed the roles of COX-2 in the carcinogenesis and ana- lyzed COX-2 inhibitors for the chemoprevention of esophageal cancer.