| 大鼠胸主动脉球囊损伤后内膜增生的实验研究 |
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| 引用本文： | 姚园,江洪,李庚山,徐超. 大鼠胸主动脉球囊损伤后内膜增生的实验研究[J]. 医学临床研究, 2006, 23(4): 520-522 |
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| 作者姓名： | 姚园 江洪 李庚山 徐超 |
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| 作者单位： | 武汉大学人民医院心内科,湖北,武汉,430060;武汉大学人民医院心内科,湖北,武汉,430060;武汉大学人民医院心内科,湖北,武汉,430060;武汉大学人民医院心内科,湖北,武汉,430060 |
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| 摘 要： | 【目的】制作大鼠胸主动脉球囊损伤的动物模型．观察内膜增生和内皮修复的动态变化。【方法】将32只雄性SD大鼠随机分为时照组（8只）和实验组（24只），于球囊损伤术后d7、d14．和d28处死实验组动物。分别进行伊文思蓝染色观察内皮覆盖情况，增殖细胞核抗原（PCNA）免疫组化染色和组织形态学定量分析。【结果】和时照组相比，球囊损伤后内膜面积与中膜面积的比值（IA／MA）和再生内皮覆盖率呈持续性增加（P〈0．01），而反映血管平滑肌增殖活性的PCNA阳性表达指数呈持续性下降（P〈0．01）。【结论】内膜增生是管腔狭窄的主要因素．而内皮损伤是这一过程的始动因素。
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| 关 键 词： | 主动脉 胸/损伤 大鼠 |
| 文章编号： | 1671-7171(2006)04-0520-03 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2005-10-21 |
Experimental Study of Neointimal Formation of Balloon Injured Rat Aorta |
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| YAO Yuan, JIANG Hong, LI Geng-shan.et al. Experimental Study of Neointimal Formation of Balloon Injured Rat Aorta[J]. Journal of Clinical Research, 2006, 23(4): 520-522 |
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| Authors: | YAO Yuan JIANG Hong LI Geng-shan.et al |
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| Affiliation: | Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | [Objective]To observe the dynamic change of neointimal formation and endothelial regeneration of balloon injured rat aorta. [Methods]Thirty-two male SD rats were randomly divided into control group and 3 experiment groups, 8 rats in each experiment group were killed on 7. 14, 28 days after injury. The endothelial regeneration rate. IA/MA ratio. PCNA expression index and morphological changes were detected. [Results] Compared with control group, the endothelial regeneration rate and IA/MA ratio increased continuously, and the PCNA expression index decreased gradually. [Conclusion]The neointimal formation is the main factor of restenosis, and the endothelial injury is the initial factor. |
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| Keywords: | aorta.thoracic/IN rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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