| 癌旁喉黏膜端粒酶活化的意义 |
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| 引用本文： | 陈鸣,杨蓓蓓,张行. 癌旁喉黏膜端粒酶活化的意义[J]. 临床耳鼻咽喉头颈外科杂志, 2004, 18(5): 286-287 |
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| 作者姓名： | 陈鸣 杨蓓蓓 张行 |
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| 作者单位： | 1. 浙江大学医学院附属第二医院耳鼻咽喉科,杭州,310009
2. 浙江大学肿瘤研究所 |
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| 摘 要： | 目的 :研究癌旁非癌变喉黏膜端粒酶的表达 ,探讨端粒酶的活化在喉癌扩展及复发中的作用。方法 :采用端粒重复序列扩增法 ,结合组织病理学观察。结果 :癌旁阴性切缘以外喉黏膜的端粒酶阳性率高于喉癌组织 (P <0 .0 5 )。结论 :端粒酶的激活发生在喉癌的形态学改变之前 ,可能提示有恶性转化潜能的细胞扩散。
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| 关 键 词： | 喉肿瘤 端粒酶 |
| 文章编号： | 1001-1781(2004)05-0286-02 |
| 修稿时间： | 2003-10-24 |
Evaluation of telomerase activation in laryngeal mucosa adjacent to carcinoma |
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| CHEN Ming YANG Beibei ZHANG Xing. Evaluation of telomerase activation in laryngeal mucosa adjacent to carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2004, 18(5): 286-287 |
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| Authors: | CHEN Ming YANG Beibei ZHANG Xing |
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| Affiliation: | Department of Otolaryngology, Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou, 310009, China. |
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| Abstract: | Objective:To investigate telomerase activity in laryngeal nonmalignant mucosa adjacent to carcinoma and discuss its effect on extension and recurrence of laryngeal carcinoma.Method:Telomerase repeat amplification protocol was used and combined with histological examination.Result:The positive percentage of telomerase activation was even higher in laryngeal nonmalignant mucosa distant toward surgically negative margin of carcinoma than in laryngeal carcinomas themselves (P<0.05).Conclusion:Telomerase activation occurred probably before the morphologic alteration, which may imply expansion of the cells with potential of malignant transformation. |
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| Keywords: | Laryngeal neoplasm Telomerase |
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