| 美多巴与SCH 23390 在热环境中对大鼠体温的调节作用 |
| |
| 引用本文： | 李澎灏,赵永岐,王鲁明. 美多巴与SCH 23390 在热环境中对大鼠体温的调节作用[J]. 基础医学与临床, 2000, 20(2): 68-70,73 |
| |
| 作者姓名： | 李澎灏 赵永岐 王鲁明 |
| |
| 作者单位： | 军事医学科学院基础医学研究所!北京100850(赵永岐，王鲁明，邢成，范明)，深圳市红十字会医院药剂科!深圳518029(李澎灏) |
| |
| 基金项目： | 国家自然科学基金!（No．39670627） |
| |
| 摘 要： | 观察美多巴和多巴胺Ｄ１受体拮抗剂ＳＣＨ２３３９０对大鼠体温的调节作用。实验大鼠预先分别给予两种药物后置于相同的热环境中，观察体温升高速率，同时用放射配基结合法检测纹状体中Ｄ１Ｒ的平衡解离常数和最大结合容量，用放射反应试剂盒测定纹状体中ｃＡＭＰ的浓度，用流式细胞仪检测纹状体细胞中钙调素的相对活性。结果表明：多巴胺受体激动剂美多巴能明显加快动物升温，而Ｄ１Ｒ拮抗剂ＳＣＨ２３３９０则明显阻升温，两种药物
|
| 关 键 词： | 体温调节 多巴胺受体 美多巴 SCH23390 |
Regulatory effcts of madopar and SCH23390 on baby temperature of rats in heat environment |
| |
| LI Peng-hao,ZHAO Yong-qi,WANG Lu-ming. Regulatory effcts of madopar and SCH23390 on baby temperature of rats in heat environment[J]. Basic Medical Sciences and Clinics, 2000, 20(2): 68-70,73 |
| |
| Authors: | LI Peng-hao ZHAO Yong-qi WANG Lu-ming |
| |
| Affiliation: | LI Peng-hao,ZHAO Yong-qi~1,WANG Lu-ming |
| |
| Abstract: | The effects of Madopar and SCH23390 on rats' thermoregulation were observed. Rats were put into the hot environment after been treated with Madopar or SCH23390, and the raise rate of rat body temperature were analyzed. At the same time, the Kd and Bmax of D_1 dopamine receptor in rat striatum were identified with radioligand binding assay. The concentration of cAMP and the content of CaM were respectively examined by radio-competitive binding reaction and FACS. The results showed that Madopar accelerated the body temperature raise of rat suffering heat stress;the antagonist SCH23390, however, blocked the raise rate. The different effects of these drugs on thermoregulation may be induced by D_1,R and D_2, R and have different molecule mechanism. |
| |
| Keywords: | thermoregulation: dopamine receptor madopar SCH23390: striatum |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
