| 外周血T淋巴细胞与腰椎间盘突出类型及直腿抬高试验的相关性 |
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| 引用本文： | 田鹏,马信龙,王涛,马剑雄. 外周血T淋巴细胞与腰椎间盘突出类型及直腿抬高试验的相关性[J]. 中国组织工程研究与临床康复, 2010, 14(2). DOI: 10.3969/j.issn.1673-8225.2010.02.037 |
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| 作者姓名： | 田鹏 马信龙 王涛 马剑雄 |
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| 作者单位： | 1. 天津医科大学总医院骨科,天津市,300052
2. 天津医科大学总医院骨科,天津市,300052;天津市天津医院,天津市,300211 |
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| 基金项目： | 天津医科大学科学基金项目，天津市应用基础及前沿研究计划 |
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| 摘 要： | 目的:观察腰椎间盘突出症患者外周血T淋巴细胞变化水平,探讨患者外周血T淋巴细胞水平变化与其突出类型、体征的关系.方法:收集2008-01/10在天津医科大学总医院需外科治疗的49例单阶段腰椎间盘突出症患者外周血,男26例,女23例.发病部位:L_(4～5) 22例,L_5S_1 27例.治疗前直腿抬高试验阳性34例,阴性15例.根据术中所见腰椎间盘位置分为破碎疝出组30例和退变突出组19例.以同期健康献血者20名为对照组.采用流式细胞仪检测外周血T淋巴细胞分类.结果:破碎疝出组CD3~+、CD4~+、CD4~+/D8~+水平较对照组高(P<0.05),CD8~+低于对照组(P<0.05);直腿抬高试验阳性组CD4~+、CD4~+/CD8~+水平较阴性组高,阳性组CD8~+水平较阴性组低,差异有显著性意义(P<0.05).破碎疝出组直腿抬高试验试验阳性率高于退变突出组直腿抬高试验阳性率.结论:腰椎间盘疝出后出现外周血T淋巴细胞免疫变化,且其不同病理类型也存在差异,T细胞介导免疫反应在患者体征发生、发展中起重要的作用.直腿抬高试验可能有助于证实突出间盘对神经根的损伤及治疗方式的选择.
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| 关 键 词： | 椎间盘移位 分型 T淋巴细胞亚群 直腿抬高试验 |
Correlation of peripheral blood T lymphocytes with the type of lumbar disc herniation and straight leg raising test |
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| Tian Peng,Ma Xin-long,Wang Tao,Ma Jian-xiong. Correlation of peripheral blood T lymphocytes with the type of lumbar disc herniation and straight leg raising test[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(2). DOI: 10.3969/j.issn.1673-8225.2010.02.037 |
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| Authors: | Tian Peng Ma Xin-long Wang Tao Ma Jian-xiong |
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| Affiliation: | Tian Peng1,Ma Xin-long1,2,Wang Tao1,Ma Jian-xiong11Department of Orthopedics,General Hospital of Tianjin Medical University,Tianjin 300052,China,2Tianjin Hospital,Tianjin 300211 |
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| Abstract: | OBJECTIVE:To observe peripheral T lymphocytes changes of patients with lumbar disc herniation,and investigate the relationship between the type of herniation,signs and T lymphocyte subsets. METHODS:Blood samples from 49 patients with single-level lumbar intervertebral disc herniation were collected from General Hospital of Tianjin Medical University from January to October 2008,including 26 males and 23 females. There were 22 cases of L4-5 and 27 cases of L5S1. In the straight leg raising (SLR) test before ... |
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