| 补硒对克山病病区粮饲养大鼠心肌线粒体单胺氧化酶活性的影响 |
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| 引用本文： | 周兰华,范高峰,徐光禄,王世臣,张凯.补硒对克山病病区粮饲养大鼠心肌线粒体单胺氧化酶活性的影响[J].营养学报,1993(1). |
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| 作者姓名： | 周兰华 范高峰 徐光禄 王世臣 张凯 |
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| 作者单位： | 西安医科大学生物化学教研室，克山病研究室，西安医科大学生物化学教研室，克山病研究室，西安医科大学生物化学教研室 西安 710061，西安 710061，西安 710061 |
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| 基金项目： | 国家《七五》攻关资助项目 |
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| 摘 要： | 90只断乳两周的Spragul-Dawley纯种大鼠,随机分为低硒、补硒及常备饲料三组,分别饲以克山病病区低硒粮(含Se 0.009ppm)、克山病病区低硒粮补亚硒酸钠(含Se 0.232ppm)及常备饲料(含Se 0.169ppm),观察硒对心肌线粒体单胺氧化酶活性(MAO)的影响,结果表明:与补硒和常备饲料组相比,低硒组心肌线粒体MAO活性明显下降。饲喂30,60,90天血浆硒含量和红细胞GSH-Px活性显著下降,补硒组心肌线粒体MAO和红细胞GSH-Px活性接近常备饲料组水平。
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| 关 键 词： | 硒 克山病病区粮 心肌线粒体 单胺氧化酶 |
EFFECT OF Se-SUPPLEMENTATION ON MONOAMINE OXIDASE ACTIVITY IN MYOCARDIAL MITOCHONDRIA OF RATS FED ON GRAINS FROM KESHAN DISEASE AREA |
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| Zhou Lanhua,Fan Gaofeng,Xu Guanglu,Wang Shichen,Wang Shichen,Zhang Kai.EFFECT OF Se-SUPPLEMENTATION ON MONOAMINE OXIDASE ACTIVITY IN MYOCARDIAL MITOCHONDRIA OF RATS FED ON GRAINS FROM KESHAN DISEASE AREA[J].Acta Nutrimenta Sinica,1993(1). |
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| Authors: | Zhou Lanhua Fan Gaofeng Xu Guanglu Wang Shichen Wang Shichen Zhang Kai |
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| Abstract: | Three groups of Sprague-Dawley rats were fed on low-Se diet frow Keshan disease area, Se-supplemented diet and stock diet respectively, for observing the effect of Se on mitochoadrial monoamine oxidase (MAO) activities in myocardia. The results showed that cardiac mitochondrial MAO activities in the Se-deficient group were significantly decreased as compared to both the Se-supplemented and stock diet group, and Se content in plasma and GSH-Px activity in. red blood cells also were significantly reduced at 30, 60 and 90 days of feeding. In Se-supplemented group MAO and GSH-Px activities as well as Se content were comparable to levels in the stock diet group. |
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| Keywords: | selenium keshan disease area grains monoamine oxidase myocardial mitochondria |
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