胃癌术后早期腹腔热灌注化疗的临床观察

目的：探讨胃癌术后腹腔持续热灌注化疗的临床意义。方法：将78例胃癌术后患者随机分成治疗组和对照组。治疗组41例采用腹腔热灌注化疗联合静脉化疗，对照组37例只进行静脉化疗，比较2组的术后并发症、不良反应、局部复发率、远处转移率、1年和3年生存率。结果：2组的术后并发症及不良反应无统计学差异。治疗组的局部复发率21．95％、远处转移率17．07％，低于对照组的40．54％和37．83％，差异有统计学意义（P〈0．05）。治疗组1年和3年生存率均分别为90．24％和68．29％，高于对照组的81．68％和48．64％，其中3年生存率2组之间差异有统计学意义（P〈0．05）。结论：胃癌术后早期腹腔热灌注化疗能显著降低局部复发率和远处转移率，并提高生存率，操作简便、安全性高。

Clinical observation on early intraperitoneal hyperthermic perfusion chemotherapy in the treatment of stomach carcinoma after operation

Objective:To study the clinical effect of early intraperitoneal hyperthermic perfusion chemotherapy on stomach carcinoma after operation. Methods: A total of 78 patients with stomach carcinoma were randomly divided into two groups. The therapeutic group received an intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy (n=41). The control group were given the intravenous chemotherapy only (n=37). Postoperative complications, adverse reaction, local recurrence, distant metastasis, and 1-and 3-year survival rate were compared between the two groups. Results:There was no significant difference in the postoperative complications and adverse reaction between the two groups. The local recurrence rate and distant metastasis rate in the therapeutic group were significantly lower than the control group (21.95% vs 40.54%, 17.07% vs 37.83%, P<0.05). The 1-year and 3-year survival rate in the therapeutic group were higher than the control group (90.24% vs 81.68%, 68.29% vs 48.64%, P<0.05). Conclusions: Early postoperative intraperitoneal hyperthermic perfusion chemotherapy effectively decreased the rate of local recurrence and distant metastasis and increased the survival rate. It is safe and easy to operate.