功能性氧化石墨烯-β-环糊精/阿司匹林复合物的制备和质量评价及其抗凝血性

目的：合成新型的功能性氧化石墨烯-β-环糊精/阿司匹林（GO-DEX-β-CD/ASA）复合物，并对其进行质量评价和抗凝血性研究。方法：利用电子扫描显微镜（SEM）和X-线衍射仪（XRD）对其形貌进行表征；对生成物的包封率、回收率以及精密度进行评价，以离心法测定GO-DEX-β-CD/ASA复合物的包封率；通过溶血试验和复钙试验评价其血液相容性。结果：GO-DEX-β-CD/ASA复合物的平均回收率（n=3）为（100.3±0.32）%，包封率（n=5）为（76.08±1.06）%，溶血率低于5%，符合生物医学材料的标准。结论：GO-DEX-β-CD/ASA复合物制备工艺可行，质量控制方法简便可靠，具有良好的血液相容性。

Preparation,quality evaluation and anticoagulant properties of functional graphene oxied-β-cyclodextrin/aspirin compound

OBJECTIVE To synthesize new type GO-DEX-β-CD/ASA compound, evaluate qualities and anticoagulant properties.METHODS Microstructure of graphene oxide was characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Recovery, precision and entrapment efficiency of GO-DEX-β-CD/ASA compound were studied, and GO-DEX-β-CD/ASA compound entrapment efficiency was determined by centrifugation. Blood compatibility of GO-DEX-β-CD/ASA compound was evaluated by hemolysis test and plasma recalcification time test.RESULTS Average recovery (n=3) of GO-DEX-β-CD/ASA compound was (100.3±0.32)%, with an entrapment efficiency (n=5) of (76.08±1.06)%. Hemolysis rate of GO-DEX-β-CD/ASA compound passed relevant international standard.CONCLUSION Preparation technique of GO-DEX-β-CD/ASA compound is feasible, quality control method is convenient and reliable, and blood compatibility is good.