| 重型再生障碍性贫血的研究进展 |
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| 引用本文： | 聂玲辉, 伍志勇, 朱晓光, 商建青, 陈宝田, 朱玲玲. 重型再生障碍性贫血的研究进展[J]. 分子影像学杂志, 2017, 40(1): 85-89. doi: 10.3969/j.issn.1674-4500.2017.01.25 |
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| 作者姓名： | 聂玲辉 伍志勇 朱晓光 商建青 陈宝田 朱玲玲 |
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| 作者单位： | 1.南方医科大学 中医药学院，广东 广州 510515;;2.南方医科大学 南方医院 中医科，广东 广州 510515;;3.南方医科大学附属中西医结合医院，广东 广州 510000 |
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| 摘 要： | 重型再生障碍性贫血（SAA）是由多种病因导致的骨髓造血功能衰竭，以造血干细胞损伤、造血微环境异常及免疫功能紊乱导致严重的贫血、感染、出血为临床表现的重度骨髓衰竭性疾病。SAA 发病机制复杂，至今尚未完全明了。随着医疗水平的提高，人们对于 SAA 的认识已从宏观微观有了质的飞跃。目前对 SAA 病因的研究热点主要集中在 T 细胞亚群的异常、负性调控因子水平的改变、细胞凋亡等，现就这些方面的研究进行综述。
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| 关 键 词： | 再生障碍性贫血 发病机制 研究进展 |
| 收稿时间： | 2016-09-24 |
Research progress of severe aplastic anemia |
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| Linghui NIE, Zhiyong WU, Xiaoguang ZHU, Jianqing SHANG, Baotian CHEN, Lingling ZHU. Research progress of severe aplastic anemia[J]. Journal of Molecular Imaging, 2017, 40(1): 85-89. doi: 10.3969/j.issn.1674-4500.2017.01.25 |
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| Authors: | Linghui NIE Zhiyong WU Xiaoguang ZHU Jianqing SHANG Baotian CHEN Lingling ZHU |
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| Affiliation: | 1. College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;;2. 2Department of Traditional Chinese Medicine, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China;;3. Integrative Medicine Hospital Affiliated to Southern Medical University, Southern Medical University, Guangzhou 510000, China |
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| Abstract: | severe aplastic anemia (SAA) is a bone marrow function by a variety of causes of failure to hematopoietic stem cell damage, hematopoietic microenvironment disorders and immune dysfunction leads to severe anemia, infection, bleeding clini- cal manifestations severe bone marrow failure diseases. SAA pathogenesis of complex, has not yet fully understood. With the improvement of medical standards, people's understanding from the macro and micro SAA has been a qualitative leap. At present the cause of the SAA research focus mainly concentrated in the abnormal T cell subsets, a negative regulator of level changes and apoptosis, are reviewed on research in these areas. |
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| Keywords: | severe aplastic anemia pathogenesis study progress |
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