宫颈低度鳞状上皮内瘤变与Ki-67阳性指数的相关性

目的研究宫颈低度上皮内瘤变（CIN Ⅰ）与细胞增殖指数（Ki-67）阳性指数的相关性。方法选取我院妇科门诊100例宫颈活检诊断为宫颈低度上皮内瘤变的患者，同时检测免疫组化Ki-67，未经任何治疗，半年后病理活检及免疫组化检测Ki-67。前后病理及免疫组化Ki-67结果比对，统计患者的转变情况。结果首次宫颈活检诊断为CIN Ⅰ的患者有100例，同时检测患者Ki-67阳性指数。将100例CIN Ⅰ患者按Ki-67阳性率分为3个区间，阳性率小于3%的88例，3%~10%的10例，大于10%的2例，差异有统计学意义（P<0.05）。Ki-67阳性率小于3%的患者第2次活检病理显示病情基本无进展，3%~10%的10例患者有8例发展为CINⅡ，大于10%的2例患者全部发展为CIN Ⅲ。结论Ki-67阳性指数直接决定宫颈低度鳞状上皮内瘤变患者的转归，阳性指数越高越容易发展为CIN Ⅱ或CIN Ⅲ。

Relationship between cervical CIN I and the positive index of Ki-67

ObjectiveTo explore correlation of cervical low-alcohol intraepithelial neoplasia (CIN I) with positive index Ki-67. MethodsA total of 100 patients with cervical hypothelial neoplasm were diagnosed of cervical biopsy in our hospital. The immunohistochemical ki-67 was detected with no treatment. The histopathological biopsy and immunohistochemical detection ki-67 were examined in 6 months. The pathologic biopsy and immunohistochemical ki-67 results were compared. ResultsIn the first cervical biopsy, 100 patients were diagnosed of CIN Ⅰ. The ki-67 positive index was detected. According to the positivity rate, 100 cases of CIN Ⅰ were divided into 3 Ki-67 ranges:88 cases were less than 3%, 10 cases in 3%~10% and 2 cases were more than 10% (P<0.05). Patients with a positive rate less than 3% in the second biopsy showed no progress of disease. Eight cases in 3%~10% were developed for CIN Ⅱ. 2 cases in group of more than 10% were developed for CIN Ⅲ. ConclusionKi-67 positive index can decide the cervical low-alcohol intraepithelial neoplasia outcome of patients. The high positive index make it develop for CIN II or CIN III.