微小核糖核酸与男性不育的相关性

近年来，许多研究证明微小核糖核酸（miRNA）作用于精子的发生发展，与男性生育有着一定的联系。miR-122的靶向调控对精子的发育产生影响，hsa-miR-629-3p、hsa-miR-335-5p、hsa-miR-885-5和hsa-miR-152-3p与精子活力及密度密切相关。FMRP- miR-383调控通路的失调导致男性不育。miR-27、miR-34c-3p分别抑制了CRISP2和PLCXD3蛋白的表达，从而影响精子的形态和活力。此外，miR34b/449基因座的缺失有可能导致少弱畸精子症的发生。本文将从miRNA在精子生成中的作用、与男性不育的关系以及其在弱精症患者中的研究等几个方面进行综述。 

Correlation of MicroRNA with asthenozoospermia

In recent years, many studies have demonstrated that miRNA could act on the development of spermatozoa. It had a certain relationship with male fertility. The targeted regulation of miR-122 had an effect on the development of sperm. The hsa-miR-629-3p, hsa-miR-335-5p, hsa-miR-885-5 and hsa-miR-152-3p were closely related to sperm motility and density. The disorder of the FMRP-miR-383 regulatory pathway lead to male infertility. The miR-27、miR-34c-3p inhibited the expression of CRISP2 and PLCXD3 proteins respectively, which affected the morphology and vitality of sperm. In addition, the deletion of miR34b/449 locus could lead to the occurrence of asthenospermia. This article reviews the effect of miRNA on spermatogenesis, the relationship between miRNA and male infertility and miRNA in patients with weak spermia.