中国人群miR-146a基因rs2910164多态性与缺血性脑卒中易感性的meta分析

目的探讨中国人群miR-146aC>G（rs2910164）位点单核苷酸多态性与缺血性脑卒中遗传易感性。方法检索2015年12月前中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、维普中文科技期刊数据库（VIP）、万方数据库及PubMed、Ovid、Cochrane Library、EMBASE等数据库，搜集有关中国人群miR-146aC>G（rs2910164）位点多态性与缺血性脑卒中（IS）研究，采用NOS工具评价纳入相关性研究的质量，提取科学合理有效数据，采用Review Manager 5.0软件进行Meta分析。结果共纳入6篇文献，共有IS患者1945例，健康对照者2456例，Meta分析尚未发现miR146a rs2910164 G/C基因多态性与缺血性脑卒中易感性具有相关性：基因型G vs C：OR=0.97，95%CI（0.89~1.06），P=0.06；基因型GG vs CC：OR=0.99，95%CI（0.82~1.18），P=0.88；基因型GC vs CC：OR=1.02，95%CI（0.90~1.17），P=0.75；基因型GG+GC vs CC：OR=1.01，95%CI（0.90~1.15），P=0.82。结论本研究尚未发现中国人群miR-146aC>G（rs2910164）位点多态性与缺血性脑卒中易感性之间具有相关性。

Association between miR-146a (rs2910164) gene polymorphism and susceptibility to ischemic stroke in Chinese population: a meta-analysis

ObjectiveTo investigate the association between miR-146a gene polymorphism and Ischemic stroke (IS) in Chinese population. MethodsPublications in PubMed, Ovid, Cochrane Library EMBASE, CNKI, VIP and Wangfang Datebase were retrieved up to December 2015. Studies of investigating association between miR-146aC>G (rs2910164) and IS in Chinese population were included. Quality of inclubed studies were evaluated by a Newcastle-Ottawa Scale (NOS) tool.The valied data were extracted and analyzed by Review Manager5.0 software. ResultsSix studies involving 1945 patients of IS and 2456 controls were included. No association between miR-146a rs2910164 polymorphism and the risk of IS was observed [G vs C: OR=0.97, 95%CI: (0.89-1.06), P=0.06]; [GG vs CC: OR=0.99, 95%CI: (0.82-1.18), P=0.88]; [ GC vs CC: OR=1.02, 95%CI (0.90-1.17), P=0.75]; [GG+GC vs CC: OR=1.01, 95%CI (0.90-1.15), P=0.82]. ConclusionThe Meta-analysis suggested that the rs2910164 polymorphism in miR-146a is not associated with IS in Chinese population.