Rab38在口腔鳞癌中的表达及临床意义

目的:探讨Rab38在口腔鳞状细胞癌中的表达及其临床意义。方法:采用qRT-PCR法检测60对口腔鳞癌及配对癌旁正常组织中Rab38 mRNA的表达,采用免疫组织化学方法检测149例口腔鳞癌中Rab38蛋白的表达情况,分析Rab38的表达与口腔鳞癌患者临床病理特征及预后的关系。结果:口腔鳞癌组织中的Rab38的mRNA和蛋白表达水平都高于配对癌旁正常组织;Rab38表达与TNM分期和淋巴结转移有关;Rab38高表达的患者总生存时间少于Rab38低表达患者;Rab38表达水平是影响患者总生存率的独立危险因素。结论:Rab38在口腔鳞癌中高表达与患者不良预后关系密切,Rab38可能与口腔鳞癌的发生、发展有关,并可作为判断患者预后的指标。

Expression and Clinical Significance of Rab38 in Oral Squamous Cell Carcinoma

Objective: To investigate the expression of Rab38 in oral squamous cell carcinoma and its clinical significance. Methods: Rab38 mRNA expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR) in 60 matched OSCC and adjacent non-tumorous tissues. Expression of Rab38 was evaluated by immunohistochemistry in 149 cases of OSCC and matched adjacent non-tumorous tissues. Relationships between protein expression level and clinicopathological parameters were evaluated. Results: Rab38 was over-expressed in OSCC tissues. Clinical analysis indicated that high expression of Rab38 was obviously associated with TNM stage and lymph node metastasis. OSCC patients with high levels of Rab38 expression had shorter overall survival (OS). Multivariate cox regression analysis demonstrated that Rab38 expression remained an independent prognosis. Conclusion: Overexpression of Rab38 is closely related to poor prognosis. Rab38 may contribute to the development of OSCC, and may be used as a biomarker for evaluating outcomes.