基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系

动脉粥样硬化是冠心病、脑梗死、外周血管病的主要原因，严重威胁到人类的健康和生命。尤其是冠心病，动脉粥样硬化是其最重要因素之一，主要是由于各种原因引起血管内皮细胞损伤，破坏屏障功能，血液中各种巨噬细胞广泛侵入内膜，形成以脂质为主的粥样斑块，引起血管重构，进一步发展，可引起斑块破裂。基质金属蛋白酶是一组几乎能降解血管外细胞基质所有成分的一组酶，在动脉硬化斑块的区域可过度表达，降解基质，引起斑块破裂、出血，形成继发血栓，引发急性冠状动脉综合征。本文着重从基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系作一综述。 

Relationship between the serum matrix metalloproteinase levels,atherosclerosis and plaque rupture

Atherosclerosis is a major cause of coronary heart disease(CHD), cerebral infarction and peripheral vascular disease. It is a serious threat to human health and disease ,especially CHD. Atherosclerosis is one of the most important factor , mainly due to various reasons that cause vascular endothelial cell damage and destroy its barrier function. As a consquence, many kinds of macrophages in the blood invade lining widely to form the atheromatous plaque with a mass of lipids. Eventually it will evolve into vascular remodeling. Sometimes, it may cause plaque rupture if the situation develops further. Matrix metalloproteinase is a group of enzymes that can almost degrade all off constituents of Vascular extracellular matrix. It can be expressed excessively in the areas with plentiful atherosclerotic plaques and degrade matrix to cause plaque rupture, bleeding and form Secondary thrombosis. At last, acute coronary syndrome occurs. This article mainly make a literature review about the relationship between serum matrix metalloproteinase levels and atherosclerosis and plaque rupture emphatically.