2012-2014年南京地区34家医院抗癫痫药物利用分析

目的: 评价南京地区医院抗癫痫药的应用现状及趋势。方法: 对南京地区34家医院2012-2014年抗癫痫药的品种、用量、销售金额、用药频度等进行回顾性统计、分析。结果: 南京地区抗癫痫药销售金额逐年增加。各年度新型抗癫痫药销售金额均占抗癫痫药总销售金额的六成左右,DDDs所占比例从2012年的35.43%增长至2014年的45.53%。金额排序中丙戊酸钠各年度一直占据36%左右,稳居第一;新型抗癫痫药加巴喷丁、左乙拉西坦、奥卡西平销售金额逐年大幅增加,苯妥英钠、托吡酯年销售金额略有起伏。DDDs排序中丙戊酸钠以绝对优势稳居第一;新型抗癫痫药除托吡酯外用药频度均呈逐年增加趋势,而传统AEDs除丙戊酸钠外均逐年降低。结论: 南京地区抗癫痫药丙戊酸钠、奥卡西平选用倾向大,传统抗癫痫药丙戊酸钠在抗癫痫药中仍占据重要地位,新型抗癫痫药如奥卡西平、左乙拉西坦、拉莫三嗪、加巴喷丁等不良反应、耐受性、对肝药酶的影响性等优于传统抗癫痫药,市场前景良好。

Analysis of utilization of antiepileptic drugs in 34 hospitals in Nanjing area from 2012 to 2014

OBJECTIVE To evaluate current state and trend of utilization of antiepileptic drugs in hospitals in Nanjing area.METHODS Utilization of antiepileptic drugs in 34 hospitals in Nanjing area from 2012 to 2014 were analyzed retrospectively in terms of drug varieties, dose, sale amount and DDDs, etc.RESULTS Sale amount increased yearly for antiepileptic drugs in this area, and accounted for about 60% for new antiepileptic drugs in total sale.DDDs increased from 35.43% in 2012 to 45.53% in 2014.Sale amount accounted for about 36% for sodium valproate, which ranked the first, and increased rapidly yearly for gabapentin, levetiracetam and oxcarbazepine, but had slight fluctuations for phenytoin and topiramate.DDDs overwhelmingly ranked the first for sodium valproate, and increased yearly for new antiepileptic drugs except for topiramate, but decreased yearly for traditional antiepileptic drugs except for sodium valproate.CONCLUSION Sodium valproate and oxcarbazepine are more chosen in Nanjing.Traditional antiepileptic drug sodium valproate still occupies an important position.New antiepileptic drugs inluding oxcarbazepine, levetiracetam, lamotrigine and gabapentin, etc.are superior to traditional ones in side effects, tolerability and effects on liver enzymes, and have a good market prospect.