MRI评估肝细胞癌经导管动脉化疗栓塞术疗效的研究进展

目的 总结MRI评估肝细胞癌(HCC)患者经导管动脉化疗栓塞术(TACE)术后疗效的研究进展。方法 在中国生物医学文献数据库、PubMed和Embase数据库,以肝细胞癌、经导管动脉化疗栓塞、磁共振成像为关键词,检索1990年1月—2016年3月有关HCC患者TACE术后疗效评估的相关文献,进行分析总结。结果 MRI技术种类丰富,可进行平扫、增强扫描和各种功能成像,通过监测水扩散、血供、代谢和血氧水平等多种形式,评估HCC患者TACE术后疗效。但各种MR成像序列都有各自的优缺点,限制了其在临床上的广泛应用。结论 MRI在评价HCC患者TACE治疗效果方面具有重要的意义,多种成像序列联合使用效果会大大增加。随着相关研究的深入、技术的进步,MRI在评估HCC患者TACE术后疗效方面具有广阔的应用前景。

The application of MRI in evaluating the therapeutic efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma

Objective To discuss the progress on MRI in evaluating the response of hepatocellular carcinoma after transcatheter arterial chemoembolization (TACE). Methods The literatures related to the evaluations of TACE for HCC from January 1990 to March 2016 were searched and analyzed in CBM, PubMed and Embase with key words “hepatocellular carcinoma”, “transcatheter arterial chemoembolization” and “magnetic resonance imaging”. Results There are many types of MRI, contributing to evaluate the efficacy of TACE for HCC by plain scan, contrast-enhanced MRI and various fMRI, monitoring water diffusion, blood supply, metabolism and blood oxygen level; however, the widely clinical application on clinic are restrained due to the disadvantages of each MRI. Conclusions MRI plays an important role in assessing the effects of TACE for hepatocellular carcinoma, especially when two or more MRI types are combined. With the further study and development of the technology, MRI will become an unparalleled method in evaluating the efficacy of TACE for HCC.