聚乳酸-羟基乙酸共聚物载药微球性质及缓释行为的影响因素

聚乳酸-羟基乙酸共聚物（PLGA）包裹药物制成缓释微球是药物缓释方向的研究热点，PLGA微球作为载体，具有良好的生物相容性和降解性，但载药微球的性质和释药性能易受很多因素影响，如PLGA相对分子质量，LA/GA比例，微球制备工艺等，这些因素对载药体系在生物医学领域的应用造成一定限制。结合国内外相关文献，本文综述了PLGA微球在制备及释药过程中，影响其理化性质和重要性能的因素，包括载药量，包封率，突释问题等方面，为PLGA微球进一步研究和优化提供思路。

Influencing factors of property and drug releasing of drug-loaded poly(D,L-lactide-co-glycolide) microspheres

Microspheres, which are composed by drugs encapsulated with poly (D, L-lactide-co-glycolide) (PLGA), have been widely studied in recent years. PLGA microsphere has good biodegradable and biocompatible properties, however, property of drug-loaded microsphere and drug releasing can be affected by many factors, such as molecular weight of PLGA, LA/GA ratio and preparation techniques, which restrict application of drug-loading system in biomedical field. This article has summarized influencing factors which affect important performance of PLGA microspheres in preparation and drug-releasing processes such as drug loading efficiency, encapsulation and burst releasing problem, to provide thoughts for further investigation and optimization of PLGA microspheres.