癌胚抗原相关细胞黏附分子6在胆管癌中的表达及其意义

目的:检测胆管癌患者胆汁中癌胚抗原相关细胞黏附分子6（CEACAM6）的水平并判断其对胆管癌的诊断价值。方法:选取因胆管梗阻行手术治疗的患者63例，根据术后病理结果分为良性组（n=32）和胆管癌组（n=31）。于术中留取患者胆汁，应用ELISA法测定CEACAM6水平。应用Wilcoxon Rank Sum、线性回归、多元回归以及受试者工作特征曲线（ROC）评估CEACAM6对胆管癌的诊断价值。结果:与胆管癌组相比，良性组患者年龄更小，女性比例更高，CEACAM6水平更低（8.5 ng/mLvs.39ng/mL，P≤0.001）。ROC曲线显示，当CEACAM6水平大于14 ng/mL时，其诊断胆管癌的敏感性为87.5%，特异性为69.1%。多元回归分析显示，碱性磷酸酶（ALP）和支架数与CEACAM6相关。结论:胆管癌患者CEACAM6水平升高，且可作为胆管癌的诊断指标。

Expression and diagnostic value of biliary carcinoembryonic antigen-related cellular adhesion molecule 6 in Cholangiocarcinoma

Objective :To detect the level of CEACAM6 in the bile of patients with biliary cancer and to explore）its diagnostic value for cholangiocarcinoma.Methods: Sixty-three patients were enrolled in this study and were divided into cholangiocarcinoma group（n=32） and benign group（n=31）.Bilewas collected during operation. The concentration of CEACAM6 was quantified by sandwich enzyme-linked immunosorbent assay (ELISA) and correlated with pathologic diagnosis. Diagnostic capability of CEACAM6 was evaluated by Wilcoxon rank-sum, linear regression, multiple regression, and receiver operating characteristic (ROC) curve analysis.Results:Patients in the benign group were younger, predominantly female, and had lower median biliary CEACAM6 levels than patients in the cholangiocarcinoma group (8.5 ng/mLvs. 39 ng/mL; P≤0.001). ROC curve analysis determined CEACAM6 to be a positive predictor and a CEACAM6 level >14 ng/mL was associated with 87.5% sensitivity, and69.1% specificity. Multiple regression analysis suggested elevated alkaline phosphatase and the presence of biliary endoprosthesesmayinfluence CEACAM6 levels. Conclusion: Biliary CEACAM6 level may increase in patients with cholangiocarcinoma and can identify cholangiocarcinoma.